Lidocaine hydrochloride synthesis
- Product Name:Lidocaine hydrochloride
- CAS Number:73-78-9
- Molecular formula:C14H23ClN2O
- Molecular Weight:270.8
137-58-6
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73-78-9
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$40.00/1g
Yield:73-78-9 100%
Reaction Conditions:
with hydrogenchloride in diethyl ether;
Steps:
Preparationof Lidocaine hydrochloride monohydrate:
Dry HCl was bubbled through a solution of lidocaine (3 g) in anhydrous ether (75 cm3). The salt precipitated immediately; passage of HCl continued until no further precipitate was formed.The salt was filtered and washed with liberal excess of ether to obtain it in almost quantitative yield. A portion of the salt was kept in the open atmosphere (72 h, next to a beaker containingwater as source of moisture) to obtain Lidocaine.HCl.H2O (mp is 73-74 °C in excellent agreement with literature reported mp of 73-74°C [1]). Another portion was dried under vacuum at 50°C until the mp of the salt reaches aconstant value indicating the formation of the anhydrous salt Lidocaine.HCl (closed capillary mp is 131-133°C, as compared to Lit. [2] mp of 127-132°C) for NMR spectral comparison.
References:
Badawi, Hassan M.;F?rner, Wolfgang;Ali, Shaikh A. [Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy,2016,vol. 152,p. 92 - 100] Location in patent:supporting information
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79-04-9
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87-62-7
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73-78-9
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$40.00/1g
87-62-7
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73-78-9
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576-26-1
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73-78-9
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