ChemicalBook CAS DataBase List Malonamide

Malonamide synthesis

14synthesis methods

Product Name:Malonamide
CAS Number:108-13-4
Molecular formula:C3H6N2O2
Molecular Weight:102.09

The synthesis of Malonamide is as follows:
A typical reaction was carried out in a 10 mL flask. Benzonitrile (2 mmol), CuII-4 ? (0.2 g), acetaldoxime (6 mmol) and MeOH (4 mL) were stirred at 65 °C for 4 h. The solid was filtered, washed with MeOH and the filtrate evaporated. The residue was subjected to GC-MS analysis and NMR spectroscopy. The filtered catalyst can be recycled after drying at about 150 °C for 1 h.
synthesis of Malonamide.png

109-77-3 Synthesis

109-77-3
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108-13-4
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Yield:108-13-4 98%

Reaction Conditions:

with Acetaldehyde oxime in methanol at 65; for 4 h;

Steps:

General procedure: A typical reaction was carried out in a 10 mL flask. Benzonitrile (2 mmol), Cu^II-4 ? (0.2 g), acetaldoxime (6 mmol) and MeOH (4 mL) were stirred at 65 °C for 4 h. The solid was filtered, washed with MeOH and the filtrate evaporated. The residue was subjected to GC-MS analysis and NMR spectroscopy. The filtered catalyst can be recycled after drying at about 150 °C for 1 h.

References:

Kiss, árpád;Hell, Zoltán [Tetrahedron Letters,2011,vol. 52,# 45,p. 6021 - 6023] Location in patent:experimental part

107-91-5 Synthesis