METHYL 2-FLUOROPHENYLACETATE synthesis
- Product Name:METHYL 2-FLUOROPHENYLACETATE
- CAS Number:57486-67-6
- Molecular formula:C9H9FO2
- Molecular Weight:168.16
67-56-1
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$7.29/5ml-f
451-82-1
343 suppliers
$6.00/5g
57486-67-6
101 suppliers
$31.00/5g
Yield: 100%
Reaction Conditions:
with sulfuric acidReflux;
Steps:
1.1. General procedure of synthesis of esters 3e, 7e-15e
General procedure: To an appropriately substituted phenylacetic acid (10 mmol) dissolved in dried methanol (50 mL), concentrated sulfuric acid (0.5 mL) was added dropwise.The mixture was refluxed from 7 to 9 h. Next, the solvent was evaporated, and residue was dissolved in 40 mL of ethyl acetate, washed with 0.5% NaOH andbrine. Organic layer was dried over anhydrous Na2SO4 and filtered. The solvent was evaporated to give the products as colorless oils.
References:
Łażewska, Dorota;Kurczab, Rafał;Więcek, Małgorzata;Kamińska, Katarzyna;Satała, Grzegorz;Jastrzębska-Więsek, Magdalena;Partyka, Anna;Bojarski, Andrzej J.;Wesołowska, Anna;Kieć-Kononowicz, Katarzyna;Handzlik, Jadwiga [European Journal of Medicinal Chemistry,2017,vol. 135,p. 117 - 124] Location in patent:supporting information
451-82-1
343 suppliers
$6.00/5g
57486-67-6
101 suppliers
$31.00/5g
67-56-1
734 suppliers
$7.29/5ml-f
326-62-5
253 suppliers
$5.00/5g
57486-67-6
101 suppliers
$31.00/5g