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ChemicalBook CAS DataBase List METHYL 2-PHENOXYPROPANOATE

METHYL 2-PHENOXYPROPANOATE synthesis

9synthesis methods
-

Yield:2065-24-9 186.66 g

Reaction Conditions:

Stage #1: phenolwith sodium hydrogencarbonate in toluene;Reflux;
Stage #2: 2-chloro-propionic acid methyl ester in toluene at 80; for 0.5 h;

Steps:

3.1; 4.1

To 95.06 g of 99% pure phenol,91.65 g of 99% pure sodium hydrogencarbonate and 427.77 g of toluene were added, and the mixture was refluxed and dehydrated to a water content of ≤0.5%, and 133.70 g of 99% pure methyl 2-chloropropionate was added dropwise thereto at 80 ° C to cause a reaction. After the addition is completed, the reaction is kept at this temperature for 0.5 h, the temperature is lowered to 50 ° C, filtered, and an appropriate amount of toluene is added to wash the filter cake.After drying, sodium chloride and crude 2-phenoxypropionate containing toluene are dried.Toluene was recovered by distillation, and 186.66 g of methyl 2-phenoxypropionate was obtained in an amount of 96.0%.

References:

CN108947814,2018,A Location in patent:Paragraph 0086; 0087; 0090; 0091