ChemicalBook CAS DataBase List methyl 3-bromo-5-fluoro-2-methylbenzoate

methyl 3-bromo-5-fluoro-2-methylbenzoate synthesis

6synthesis methods

Product Name:methyl 3-bromo-5-fluoro-2-methylbenzoate
CAS Number:1187318-53-1
Molecular formula:C9H8BrFO2
Molecular Weight:247.06

175278-29-2
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$9.00/1g

methyl 3-bromo-5-fluoro-2-methylbenzoate

1187318-53-1
57 suppliers
$54.00/100mg

Yield: 22 g

Reaction Conditions:

with N-Bromosuccinimide;sulfuric acid at 0 - 20; for 19 h;

Steps:

3.2 Step 2: Synthesis of Compound I-16C
Compound I-16B (15 g, 90 mmol) was added to a solution of concentrated sulfuric acid (200 mL).The ice bath was cooled to below 5 degrees Celsius and then NBS (17.8 g, 100 mmol) was added portionwise. The resulting mixture was stirred at 0 ° C for 3 hours, then at room temperature and stirred for 16 hours.Then slowly pour the mixture into ice water (2L).It was extracted with EtOAc (500 mL x 3).The combined organic layers were washed with water and brine.Drying and concentration gave Compound I-16C (22 g).

References:

Guangzhou Dankang Pharmaceutical Biological Co., Ltd.;Xu Yong;Huang Lu;Lin Dang;Hu Hai CN110092745, 2019, A Location in patent:Paragraph 0126-0128; 0132; 0133