N-Methyl-2,3-difluorobenzylaMine synthesis
- Product Name:N-Methyl-2,3-difluorobenzylaMine
- CAS Number:906645-41-8
- Molecular formula:C8H9F2N
- Molecular Weight:157.16
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Yield:-
Reaction Conditions:
Stage #1: methylamine hydrochloridewith potassium carbonate in methanol at 20; for 0.5 h;
Stage #2: 2,3-difluorobenzaldehyde in methanol at 20; for 1 h;
Stage #3: with methanol;sodium tetrahydroborate at 0 - 20; for 3 h;
References:
Ren, Yan;Su, Yaning;Sun, Liming;He, Sudan;Meng, Lingjun;Liao, Daohong;Liu, Xiao;Ma, Yongfen;Liu, Chunyan;Li, Sisi;Ruan, Hanying;Lei, Xiaoguang;Wang, Xiaodong;Zhang, Zhiyuan [Journal of Medicinal Chemistry,2017,vol. 60,# 3,p. 972 - 986]