Nicotine synthesis

8synthesis methods

Product Name:Nicotine
CAS Number:54-11-5
Molecular formula:C10H14N2
Molecular Weight:162.23

The nicotine molecule consists of a pyrrolidine ring attached to a pyridine ring by a bondbetween carbon atoms in the two-ring systems. Nicotine was isolated in impure form fromtobacco in 1809 by Louis Nicholas-Vauquelin (1763–1829). Vauquelin called the substancenicotianine. In 1826, Wilhelm Posselt (1806–1877) and Karl Ludwig Reimann (1804–1872),medical students at Heidelberg University, isolated pure nicotine and published dissertationson its pharmacology in 1828. Louis Henri Melsens (1814–1886) determined nicotine’sempirical formula. Amé Pictet (1857–1937) and P. Crépieux reported the synthesis of nicotine in 1903.

50-00-0 Synthesis

50-00-0
838 suppliers
$10.00/25g

494-97-3
71 suppliers
$109.00/100mg

54-11-5
8 suppliers
$18.30/250mg

Yield:54-11-5 95%

Reaction Conditions:

with formic acid in ethanol;water at 20;Inert atmosphere;

Steps:

1.4; 2.4; 3.4; 5.4; 6.4

(4) At room temperature, in a nitrogen atmosphere,(S)-(-)-3-pyrrolidinylpyridine (14.8g, 0.1mol) was added to the reactor,50 mL of ethanol, 10 mL of water, 2 mL of formic acid, and paraformaldehyde (4.0 g, 0.13 mol) were added to heat the reaction, and the reaction process was monitored by HPLC. After the reaction was completed, the temperature was cooled to 10°C, and the pH of the system was adjusted to 11.0 with a liquid alkali solution. Extract three times with toluene. The toluene phases were combined and concentrated under reduced pressure to recover toluene. Then high vacuum and reduced pressure distillation, vacuum degree -0.098Mpa, to obtain 15.5 g of colorless oil (S)-(-)-nicotine, the yield is 95%, the HPLC purity is 99.2%, and the ee% value is 99%.

References:

CN113999084,2022,A Location in patent:Paragraph 0022; 0027; 0028; 0033; 0034; 0039; 0040; 0045

494-97-3
71 suppliers
$109.00/100mg

74-88-4
339 suppliers
$15.00/10g

54-11-5
8 suppliers
$18.30/250mg

References

486-56-6 Synthesis

486-56-6
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$23.80/1mL

54-11-5
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$18.30/250mg

References

Pyridine, 2-bromo-5-[(2S)-1-methyl-2-pyrrolidinyl]-

96400-85-0
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inquiry

54-11-5
8 suppliers
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References

22083-74-5 Synthesis

22083-74-5
104 suppliers
$90.00/100mg

54-11-5
8 suppliers
$18.30/250mg

25162-00-9
20 suppliers
$716.10/50MG

References

Nicotine Related Search:

Pyridine Pyrrolidine Methylparaben Parathion-methyl (-)-COTININE Isonipecotic acid 2-Chloronicotinic acid 6-Methylnicotinic acid (+/-)-NICOTINE Methyl 6-methylnicotinate