ChemicalBook CAS DataBase List PYRIDINE, 2-CHLORO-5-(PHENYLMETHOXY)-

PYRIDINE, 2-CHLORO-5-(PHENYLMETHOXY)- synthesis

5synthesis methods

Product Name:PYRIDINE, 2-CHLORO-5-(PHENYLMETHOXY)-
CAS Number:84611-43-8
Molecular formula:C12H10ClNO
Molecular Weight:219.67

41288-96-4 Synthesis

41288-96-4
326 suppliers
$8.00/1g

100-39-0
420 suppliers
$10.00/10g

84611-43-8
47 suppliers
$45.00/50mg

Yield:84611-43-8 100%

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide at 60; for 18 h;

Steps:

166-1 (166-1) Synthesis of 5- (benzyloxy) -2-chloropyridine (Compound 166-1)

6-chloropyridin-3-ol (1.0 g),Benzyl bromide (1.5 g) and potassium carbonate (2.4 g)Was dissolved in DMF (40 mL) and stirred at 60 ° C. for 18 hours.After filtering the reaction solution,The solvent of the obtained filtrate was distilled off under reduced pressure to obtain a residue,Purification by silica gel column chromatography (hexane-ethyl acetate)5- (benzyloxy) -2-chloropyridine1.3 g (yield quant.) Was obtained.

References:

JP2017/171619,2017,A Location in patent:Paragraph 0233; 0235

41288-96-4 Synthesis

41288-96-4
326 suppliers
$8.00/1g

100-44-7 Synthesis