API

Active Pharmaceutical Ingredients (API), popularly speaking, are the raw materials of medicines, only pharmaceutical raw materials are processed into pharmaceutical preparations , can they become medicines available for clinical use, so drugs we usually eat are the finished drugs through processing. Active Pharmaceutical Ingredients based on its sources can be divided into two major categories ,including chemical synthetic drugs and natural chemical drugs. Chemical synthetic drugs can be divided into organic synthetic drugs and inorganic synthetic drugs. Inorganic synthetic drugs are inorganic compounds ( very few is element), such as aluminum hydroxide, magnesium trisilicate which are used for the treatment of gastric and duodenal ulcers ; organic synthetic drugs are mainly composed of drugs made by basic organic chemical raw materials, through a series of organic chemical reactions (such as aspirin, chloramphenicol, caffeine, etc.). Natural chemical drugs ,based on its sources,can be divided into two categories including biochemical drugs and plant chemical drugs. Antibiotics are generally made by the microbial fermentation, which belongs to the biochemistry category. A variety of semi-synthetic antibiotics occurs in recent years,which are biosynthesis and chemical synthesis combining products.Among active Pharmaceutical Ingredients, the organic synthetic drugs varieties, yields and values have the largest proportion,which are the main pillars of the chemical and pharmaceutical industries. The quality of active Pharmaceutical Ingredients decides whether the formulation is good or bad , so its quality standards are very strict ,countries in the world have developed national pharmacopoeia standards and strict quality control methods for its widely used active Pharmaceutical ingredients.

Pyrroloquinoline quinone: Food sources, benefits and side effects

Pyrroloquinoline quinone (PQQ) is a quinone described as a cofactor for many bacterial dehydrogenases and reported to have effects on mammalian cell/tissue metabolism.

Mar 24,2025  API

FDA-approved drug Tofacitinib citrate: Brand name,Indications and Side Effects

Tofacitinib citrate is a Janus kinase (JAK) inhibitor, it treats adults with moderate to severe rheumatoid arthritis, active psoriatic arthritis, active ankylosing spondylitis, and moderate to severe

Mar 24,2025  API

Mirogabalin besylate:Indications, Advantages,Mechnaism of action and Side effects

Mirogabalin besylate is indicated for patients with peripheral neuropathic pain and central neuropathic pain after spinal cord injury and stroke, many of whom are elderly.

Mar 24,2025  API

Macitentan: a dual endothelin-receptor antagonist

Macitentan is an orally active, non-peptide, potent dual ERA and macitentan selectively inhibits the binding of endothelin-1 (ET-1) to ETA and ETB receptors.

Mar 24,2025  API

JAK inhibitor Upadacitinib:FDA approval,Brand name,Indications and Side effects

Upadacitinib received FDA approval on August 16, 2019, based on positive and promising results from its multinational phase III trials in subjects with moderate to severe rheumatoid arthritis.

Mar 24,2025  API

Selpercatinib (LOXO-292):Indications, Mechnaism,Clinical trials and Side effects

Selpercatinib (LOXO-292) is a highly selective RET inhibitor with activity across known oncogenic RET fusions and mutations.

Mar 21,2025  API

Fruquintinib:Indications,Trials and Side effects

Fruquintinib, as an oral tyrosine kinase inhibitor (TKI), effectively suppresses vascular endothelial growth factor/vascular endothelial growth factor receptor (VEGF/VEGFR) signaling and inhibits cell

Mar 21,2025  API

Pirfenidone: From Synthesis to Its Role in Treating IPF

Pirfenidone is an orally available pyridinone derivative that inhibits collagen formation and is used to treat idiopathic pulmonary fibrosis.

Mar 21,2025  API

Flunixin meglumine: An efficient and cost-effective drug

Flunixin meglumine is a potent, non-narcotic, nonsteroidal, analgesic agent with anti-inflammatory and antipyretic activity.

Mar 21,2025  API

(±)-Equol: Structure, Benefits and Side Effects

?(±)-Equol is an isoflavone metabolite formed from daidzein/daidzein by bacteria in the small intestine and distal colonic regions.

Mar 20,2025  API
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