Active Pharmaceutical Ingredients (API), popularly speaking, are the raw materials of medicines, only pharmaceutical raw materials are processed into pharmaceutical preparations , can they become medicines available for clinical use, so drugs we usually eat are the finished drugs through processing. Active Pharmaceutical Ingredients based on its sources can be divided into two major categories ,including chemical synthetic drugs and natural chemical drugs. Chemical synthetic drugs can be divided into organic synthetic drugs and inorganic synthetic drugs. Inorganic synthetic drugs are inorganic compounds ( very few is element), such as aluminum hydroxide, magnesium trisilicate which are used for the treatment of gastric and duodenal ulcers ; organic synthetic drugs are mainly composed of drugs made by basic organic chemical raw materials, through a series of organic chemical reactions (such as aspirin, chloramphenicol, caffeine, etc.). Natural chemical drugs ,based on its sources,can be divided into two categories including biochemical drugs and plant chemical drugs. Antibiotics are generally made by the microbial fermentation, which belongs to the biochemistry category. A variety of semi-synthetic antibiotics occurs in recent years,which are biosynthesis and chemical synthesis combining products.Among active Pharmaceutical Ingredients, the organic synthetic drugs varieties, yields and values have the largest proportion,which are the main pillars of the chemical and pharmaceutical industries. The quality of active Pharmaceutical Ingredients decides whether the formulation is good or bad , so its quality standards are very strict ,countries in the world have developed national pharmacopoeia standards and strict quality control methods for its widely used active Pharmaceutical ingredients.
Capmatinib: Pharmacodynamics, Pharmacokinetics and Adverse Events
Capmatinib targets MET exon 14 skipping mutations, inhibiting proliferation and migration in non-small cell lung cancer. It has predictable pharmacokinetics and manageable adverse reactions.
Mar 1,2024 API2,5-Bis(5-tert-butyl-2-benzoxazolyl)thiophene: Enhancing Fluorescent Stability in LDPE Films and Optical Brighteners
2,5-Bis(5-tert-butyl-2-benzoxazolyl)thiophene enhances LDPE film stability and acts as a whitening agent in textiles, plastics, and paper, with low toxicity.
Mar 1,2024 APIDiethyltoluenediamine: Uptake, Distribution, and Enhanced Properties in Polyurethaneurea and Epoxy Resins
Diethyltoluenediamine has rapid absorption and urinary excretion. It improves physical properties of PUU and epoxy resins, enhancing water resistance and mechanical strength.
Mar 1,2024 API2-Isopropylthioxanthone: Applications, Cytotoxic Effects and Detection
2-Isopropylthioxanthone is essential in UV curing, but can induce cytotoxicity and contaminate milk products. Caution and detection methods are necessary.
Mar 1,2024 APIGrowth Hormone, Human: Secretion, Signaling Pathway and Treatment in Obesity
Obesity impairs Growth hormone, human secretion but elevates IGF-I. Growth hormone, human treatment may reduce fat mass and increase lean body mass, with side effects.
Mar 1,2024 APICandesartan cilexetil: Pharmacodynamics, Pharmacokinetics and Therapeutic Uses
Candesartan cilexetil, an angiotensin II receptor antagonist, effectively reduces blood pressure and benefits patients with hypertension, renal failure, and type 2 diabetes mellitus.
Mar 1,2024 APIQ:What is the pKa of water?
A:Based on thermodynamics, the true pKa of water is 14. However, there are studies that propose a pKa of 14 or 15.74.
Feb 29,2024 APIA synthetic α2-adrenergic antagonist-Atipamezole hydrochloride
ANTISEDAN (atipamezole hydrochloride) is a synthetic α2-adrenergic antagonist.
Feb 29,2024 APICollagen: Structure, Chemical Synthesis and Biomedical applications
Collagen's triple helix, mimicked by synthetic methods like collagen-related peptides, holds promise in wound healing and tissue repair with potential biomedical applications.
Feb 29,2024 APIDiphenhydramine: Overview, Activities and Dosage
Diphenhydramine is a widely used antihistamine that alleviates allergy and cold symptoms, with sedative properties and potential side effects.
Feb 29,2024 API