In pharmacology, a drug is a chemical substance, typically of known structure, which, when administered to a living organism, produces a biological effect. A pharmaceutical drug, also called a medication or medicine, is a chemical substance used to treat, cure, prevent, or diagnose a disease or to promote well-being. Traditionally drugs were obtained through extraction from medicinal plants, but more recently also by organic synthesis. Pharmaceutical drugs may be used for a limited duration, or on a regular basis for chronic disorders.
How is Sacituzumab Govitecan Synthesised?
The overall synthetic strategy for the preparation of sacituzumab govitecan inherently consists of three separate sequential components, construction of the payload (SN-38) followed by appendage with
Jan 5，2024 Drugs
Empagliflozin protects the heart against ischemia/reperfusion-induced sudden cardiac death
Empagliflozin is a selective sodium-glucose cotransporter 2 (SGLT2) inhibitor used to lower blood sugar in adults with type 2 diabetes. Empagliflozin also exerts cardioprotective effects independent f
Jan 5，2024 Drugs
Efficacy and safety of Olmesartan Medoxomil in the treatment of hypertension
Olmesartan medoxomil is an orally administered angiotensin II receptor antagonist, selective for the angiotensin II type 1 receptor, which has established antihypertensive efficacy in adults.
Jan 5，2024 Drugs
Hydrocortisone: Clinical applications and Side Effects
Hydrocortisone is a steroid (corticosteroid) medication. It reduces pain, itching and swelling (inflammation) by suppressing the body's immune response.
Jan 5，2024 Drugs
How is Lurbinectedin synthesised?
Lurbinectedin is synthesised using tyrosine derivative as the raw material, firstly the intermediate Lurbinectedin Bridged Azocane is synthesised, and then through esterification and cyclisation.
Jan 2，2024 Drugs
Allopurinol: the treatment of elevated uric acid levels
Allopurinol, a key gout treatment, inhibits uric acid, explored for cardiovascular benefits, with optimized safety in synthesis.
Jan 2，2024 Drugs
Procaine: a general anesthesia drug
Procaine, a inhibits nerve impulses. Explored as a general anesthetic, its synthesis yields derivatives with improved efficacy and safety considerations.
Jan 2，2024 Drugs
Borofalan (10B): Synthesis and Introduction
Borofalan (10B) is synthesised using (S)-4-iodophenylalanine as raw material by chemical reaction.
Dec 29，2023 Drugs
Tofacitinib：a versatile JAK Inhibitor in autoimmune conditions
Tofacitinib, a JAK inhibitor, treats rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis by modulating immune signaling pathways.
Dec 29，2023 Drugs
How is Lonafarnib synthesised?
Lonafarnib was synthesised starting from the bromination of chloroanthranilic acid and using the lonafarnib precursor tricycle methodology based on a Grignard-induced intramolecular cyclisation reacti
Dec 27，2023 Drugs