In pharmacology, a drug is a chemical substance, typically of known structure, which, when administered to a living organism, produces a biological effect. A pharmaceutical drug, also called a medication or medicine, is a chemical substance used to treat, cure, prevent, or diagnose a disease or to promote well-being. Traditionally drugs were obtained through extraction from medicinal plants, but more recently also by organic synthesis. Pharmaceutical drugs may be used for a limited duration, or on a regular basis for chronic disorders.
Synthesis of Vericiguat
The Vericiguat synthesis was initiated with the key fluoroacrylaldehyde intermediate required to construct the fluoropyrazolopyridine core of vericiguat.
Jan 12，2024 Drugs
How to synthesise Nirmatrelvir on a large scale?
Nirmatrelvir is synthesised using saponification of bicycloproline ester.
Jan 12，2024 Drugs
How is Ibrexafungerp synthesised?
Ibrexafungerp is synthesised in two steps by chemical reaction using enfumafungin as a raw material.
Jan 9，2024 Drugs
Candesartan cilexetil in cardiovascular disease
Candesartan cilexetil is an oral angiotensin II receptor blocker. Candesartan is approved by the FDA for the treatment of hypertension in adults.
Jan 8，2024 Drugs
What are the side effects of Valsartan?
ommon side effects of Valsartan include: shortness of breath, cough , dizziness and light-headedness on waking, nausea, fatigue, diarrhoea, skin irritation , postural hypotension, hyperkalaemia, and r
Jan 8，2024 Drugs
How is Sacituzumab Govitecan Synthesised?
The overall synthetic strategy for the preparation of sacituzumab govitecan inherently consists of three separate sequential components, construction of the payload (SN-38) followed by appendage with
Jan 5，2024 Drugs
Empagliflozin protects the heart against ischemia/reperfusion-induced sudden cardiac death
Empagliflozin is a selective sodium-glucose cotransporter 2 (SGLT2) inhibitor used to lower blood sugar in adults with type 2 diabetes. Empagliflozin also exerts cardioprotective effects independent f
Jan 5，2024 Drugs
Efficacy and safety of Olmesartan Medoxomil in the treatment of hypertension
Olmesartan medoxomil is an orally administered angiotensin II receptor antagonist, selective for the angiotensin II type 1 receptor, which has established antihypertensive efficacy in adults.
Jan 5，2024 Drugs
Hydrocortisone: Clinical applications and Side Effects
Hydrocortisone is a steroid (corticosteroid) medication. It reduces pain, itching and swelling (inflammation) by suppressing the body's immune response.
Jan 5，2024 Drugs
How is Lurbinectedin synthesised?
Lurbinectedin is synthesised using tyrosine derivative as the raw material, firstly the intermediate Lurbinectedin Bridged Azocane is synthesised, and then through esterification and cyclisation.
Jan 2，2024 Drugs