How to synthesise Nirmatrelvir on a large scale?
Nirmatrelvir is synthesised using saponification of bicycloproline ester.
Jan 12，2024 Drugs
Isotretinoin: Pharmacokinetics and Effectiveness
Isotretinoin can improve bioavailability when taken with food, eliminates via feces/urine, and low-dose regimens are effective. Combining with other treatments enhances outcomes.
Jan 12，2024 API
Zirconia (Zirconium dioxide): General properties; Commercial zirconia grades and Preparation
Pure zirconium dioxide (ZrO2), also called zirconia, is a dense material (5850 kg.m–3) that exhibits a high temperature of fusion (2710°C) and a good thermal conductivity (1.8 Wm–1K–1).
Jan 11，2024 API
Magnesite: General properties; Occurrence; Mining and Industrial applications
Magnesite (MgCO3) is like alumina, that is, it is considered either as an ore for magnesium metal production or as an industrial mineral.
Jan 11，2024 API
The four commercial grades of polyethylene
Polyethylene can be prepared in four commercial grades.
Jan 11，2024 Organic Chemistry
The synthesis method of Upadacitinib hemihydrate
Upadacitinib, a once-daily orally administered selective JAK1 inhibitor developed by AbbVie, was approved for the treatment of moderate to severe RA.
Jan 11，2024 Inhibitors
Seven steps to synthesize Peficitinib hydrobromide
Peficitinib is a Janus kinase (JAK)1, JAK2, JAK3, and tyrosine kinase (Tyk)2 (pan-JAK) inhibitor recently approved in Japan for the treatment of rheumatoid arthritis.
Jan 11，2024 API
How to synthesize Tenapanor hydrochloride?
Tenapanor hydrochloride, also known as AZD-1722 and RDX5791, is a selective sodium hydrogen exchanger 3 (NHE3) inhibitor developed by Ardelyx.
Jan 11，2024 API
Q：What is the difference between D-galactose and D-glucose
A： The only difference between D-glucose and D-galactose is in carbon-4.
Jan 11，2024 Biochemical Engineering
The research on the toxicity of Trichloroacetonitrile
Trichloroacetonitrile is used as an intermediate in insecticides, pesticides, and dyes.
Jan 11，2024 Organic reagents