How is Linzagolix choline synthesised?
The synthesis of Linzagolix choline was carried out by an efficient two-component polymerisation synthesis.
Jan 30，2024 Drugs
Mycophenolate mofetil: pharmacokinetics, mechanism of action and applications in dermatology
Mycophenolate mofetilis can be converted to mycophenolic acid and inhibit T and B cell proliferation via depletion of guanosine nucleotides, showing promise in treating inflammatory skin diseases.
Jan 29，2024 API
OMadacycline (Tosylate): A Promising Tetracycline Antibiotic for the Treatment of Bacterial Infections
OMadacycline (tosylate) is a potent tetracycline antibiotic that inhibits bacterial protein synthesis by binding to ribosome, with broad effectiveness against resistant strains and moderate half-life.
Jan 29，2024 API
Apremilast Uses and Relevance to the Military
Apremilast effectively treats psoriasis and psoriatic arthritis, offering advantages for military personnel in austere conditions. Common side effects are manageable and outweighed by the benefits.
Jan 29，2024 API
Dexmedetomidine hydrochloride: Pharmacokinetic profile, pharmacodynamic profile and dosage
Dexmedetomidine hydrochloride is an intravenous medication with linear pharmacokinetics, rapid distribution and extensive liver metabolism. It can be used for ICU sedation based on RASS score.
Jan 29，2024 API
How is Loncastuximab Tesirine synthesised?
Loncastuximab Tesirine was synthesised in roughly 8 reaction steps starting from vanillin.
Jan 29，2024 Amino Acids and Proteins
How is Belzutifan synthesised?
Belzutifan was prepared by a synthetic route starting from 3,4-dihydrocoumarin, followed sequentially by the synthesis of Indanone Core and Indanone Ketal, and finally concentrating on three consecuti
Jan 29，2024 Drugs
Infigratinib: Synthesis and Introduction
Infigratinib was synthesized in a modular and convergent fashion via the union of three building blocks.
Jan 29，2024 Inhibitors
Cobalt and Flame Test
Cobalt is a lustrous very hard silvery metal belonging to a group called the "transition metals". It is always used in flame test, to eliminate the effects of sodium.
Jan 26，2024 Inorganic chemistry
Efficacy and safety of sugammadex sodium in reversing rocuronium-induced neuromuscular blockade in children: An updated
Sugammadex sodium is is more effective and safer in reversing rocuronium-induced neuromuscular blockade in children than traditional antagonistic regimens or placebos.
Jan 26，2024 Drugs