Inhibitor refers to substance that can hinder the chemical reactions, biological reactions (including immune response) and biological activity. In present time, commonly used inhibitors include immunosuppressants and inhibitors. 1. Immunosuppressive agents: immunosuppressants system refers to drug that can reduce the immune response. It can selectively suppress certain steps of the immune response and immune cells. Immune response refers to the body’s response to a variety of pathogenic substances. Some reactions are favorable to the body and can enhance the body's resistance to disease; some have adverse effects on the body and can cause tissue damage or disorders of physiological functions (allergy). Therefore, patients suffering from allergic reactions being harmful to the body should be subject to the treatment of immunosuppressant to affect the related immune processes and reduce the immune response of the body. For the treatment of various autoimmune diseases and weakening the tissue incompatibility, it has been developed of a variety of immunosuppressive agents, some of which have been widely used in clinical practice. Commonly used immunosuppressants include glucocorticoids (prednisone, prednisolone, etc.), alkylating agents (nitric oxide mustard, cyclophosphamide, thiotepa, busulfan, etc.), and antimetabolites (6- mercaptopurine, azathioprine, methotrexate, etc.). The mechanism of immunosuppressants, though not entirely clear, but is characterized by the following several aspects: ① most kinds of immunosuppressants can simultaneously inhibit cellular and humoral immunity and can be used for organ transplantation and autoimmune disease. ②Its inhibitory effect is strong for the primary immune response while the inhibitory effect against secondary response is weak. ③It can simultaneously act on normal and pathological immunity, therefore, can often lead to some complications. ④These drugs often have strong with serious adverse reactions. 2. Enzyme
Omadacycline: a protein synthesis inhibitor
Omadacycline is a first-in-class aminomethylcycline with broad-spectrum in vitro activity against Gram-positive aerobes, Gram-negative aerobes, anaerobes, and atypical bacteria.
Dec 19，2023 Inhibitors
How is GSK744 synthesised?
GSK744 (Cabotegravir) is synthesised using Cabotegravir Pyridinone as a raw material through a series of chemical reactions.
Dec 19，2023 Inhibitors
Synthesis of Levonadifloxacin Arginine
Levonadifloxacin Arginine is prepared by the reaction of levonadifloxacin and L-arginine.
Dec 19，2023 Inhibitors
Synthesis of Alalevonadifloxacin mesylate
Alalevonadifloxacin mesylate is synthesized using 2-Bromo-4,5-difluoroacetylaniline as raw material through a series of chemical reactions.
Dec 19，2023 Inhibitors
Ibotenic acid ：uses and side effects
Ibotenic acid is a powerful neurotoxin that has been used as an effective brain damage agent. Ibotenic acid has been used as a neurontoxin in rats.
Dec 18，2023 Inhibitors
Properties and applications of Mycophenolate mofetil
Mycophenolate mofetil is an immunosuppressant often used in organ transplants and other inflammations.
Sep 14，2023 Inhibitors
Synthesis and Bioactivity of 7, 8-Dihydroxyflavone
7, 8-Dihydroxyflavone is a compound with biological effects. 7,8-DHF has a strong therapeutic effect on Alzheimer's disease and can inhibit obesity by activating muscle TrkB.
Oct 24，2022 Inhibitors
Synthesis and Clinical study of Upadacitinib
Upadacitinib, a JAK1 inhibitor, has shown good efficacy in clinical trials for the treatment of a variety of autoimmune and inflammatory diseases.
Oct 18，2022 Inhibitors
Mechanism of action of Denbufylline
Denbufylline, a xanthine derivative and PDE4 inhibitor, haseffects such as vasodilatation of cerebral vessels and potent activation of the hypothalamic-pituitary-adrenal axis.
May 6，2022 InhibitorsAn AChE inhibitor---Rivastigmine
Rivastigmine is a slowly reversible AChE inhibitor and BuChE inhibitor approved for use in mild-to-moderate AD Rivastigmine is metabolized at the synapse rather than by hepatic cytochrome enzymes.
Apr 28，2022 Inhibitors