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1000025-07-9

1000025-07-9 Structure

1000025-07-9 Structure
IdentificationBack Directory
[Name]

Vadadustat
[CAS]

1000025-07-9
[Synonyms]

CS-2486
AKB-6548
PG1016548
PG-1016548
PG 1016548
Vadadustat
PG-1016548;AKB-6548
Vadadustat USP/EP/BP
Vadadustat (AKB-6548)
Vadadustat(AKB-6548/PG-1016548)
PG-1016548; PG1016548; PG 1016548; AKB-6548
Glycine, N-[[5-(3-chlorophenyl)-3-hydroxy-2-pyridinyl]carbonyl]-
AKB-6548; AKB 6548; AKB6548; PG-1016548; PG 1016548; PG1016548; B-506; B506; VADADUSTAT
[Molecular Formula]

C14H11ClN2O4
[MDL Number]

MFCD30470233
[MOL File]

1000025-07-9.mol
[Molecular Weight]

306.7
Chemical PropertiesBack Directory
[Melting point ]

172-174°C
[Boiling point ]

674.6±55.0 °C(Predicted)
[density ]

1.461±0.06 g/cm3(Predicted)
[storage temp. ]

Hygroscopic, -20°C Freezer, Under inert atmosphere
[solubility ]

DMSO (Slightly), Methanol (Slightly)
[form ]

Solid
[pka]

4.09±0.40(Predicted)
[color ]

Pale Beige to Light Beige
[Stability:]

Hygroscopic
Hazard InformationBack Directory
[Description]

Vadadustat is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) and HIF-PH3 (IC50s = 1.1 and 0.39 micromolar, respectively). It stabilizes HIF-1α in mouse hepatocyte nuclear extracts. Vadadustat (50 and 100 mg/kg) increases erythropoietin levels in mouse serum.
[Uses]

Vadadustat is a novel HIF (Hypoxia-inducible factor) stabilizer. It provides an effective anemia treatment in nondialysis-dependent chronic kidney disease.
Spectrum DetailBack Directory
[Spectrum Detail]

Vadadustat(1000025-07-9)1HNMR
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