| Identification | Back Directory | [Name]
Simvastatin-d3 | [CAS]
1002347-61-6 | [Synonyms]
Simvastatin D3 LactoneQ: What is
Simvastatin D3 Lactone Q: What is the CAS Number of
Simvastatin D3 Lactone Q: What is the storage condition of
Simvastatin D3 Lactone Q: What are the applications of
Simvastatin D3 Lactone | [Molecular Formula]
C25H35D3O5 | [MDL Number]
MFCD09832920 | [MOL File]
1002347-61-6.mol | [Molecular Weight]
421.585 |
| Hazard Information | Back Directory | [Uses]
Simvastatin-d3 is the deuterium labeled Simvastatin[1]. Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM[2]. | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] Slater, E.E., et al. Mechanism of action and biological profile of HMG CoA reductase inhibitors. A new therapeutic alternative. Drugs, 1988. 36 Suppl 3: p. 72-82. DOI:10.2165/00003495-198800363-00016 |
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