| Identification | Back Directory | [Name]
1-EBIO | [CAS]
10045-45-1 | [Synonyms]
EBIO
1-EB10
1-EBIO
Einecs 233-148-1
1-EthylbenziMidazolinone
1-ETHYL-2-BENZIMIDAZOLINONE
1-ethylbenzimidazolin-2-one
1-ETHYL-2-BENZCMIDAZOLINONE
1-Ethyl-2-benzimidazolineone
3-ethyl-1H-benzimidazol-2-one
1-Ethyl-2-benzimidazolinone,98%
1-Ethyl-1H-benzimidazole-2(3H)-one
1-EBIO, 1-Ethyl-2-benzimidazolinone
1-Ethyl-1H-benzo[d]iMidazol-2(3H)-one
1-ETHYL-1,3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE
1-Ethyl-2,3-dihydro-1H-benzimidazole-2-one
2H-Benzimidazol-2-one, 1-ethyl-1,3-dihydro-
1-Ethyl-1,3-dihydro-2H-benzo[d]imidazol-2-one
2H-Benzimidazol-2-one,1-ethyl-1,3-dihydro-(9CI)
1-ethyl-1,3-dihydro-2H-benzimidazol-2-one(SALTDATA: FREE) | [EINECS(EC#)]
233-148-1 | [Molecular Formula]
C9H10N2O | [MDL Number]
MFCD00005715 | [MOL File]
10045-45-1.mol | [Molecular Weight]
162.19 |
| Chemical Properties | Back Directory | [Melting point ]
118-120 °C(Solv: ethyl acetate (141-78-6)) | [density ]
1.161±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMSO: ≥20mg/mL | [form ]
powder | [pka]
12.29±0.30(Predicted) | [color ]
Crystalline | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| Hazard Information | Back Directory | [Description]
1-EBIO is an activator of Ca2+-sensitive K+ channels (EC50 = 490 μM in T84 human carcinoma cells).This action is sensitive to the neurotoxin charybdotoxin (Ki = 3.5 nM). In mouse colonic epithelia, 1-EBIO also activates cAMP-sensitive K+ channels, a response this is inhibited by 293B.In this type of epithelium, but not mouse nasal epithelia, 1-EBIO activates both types of channels, resulting in large Cl- secretory currents.It also activates the human intermediate conductance Ca2+-activated K+ channel (EC50 = 74 μM).1-EBIO is currently used to study the role of these types of K+ channels in diverse physiological functions. | [Uses]
1-EBIO stimulates Cl- secretion in secretory epithelia through direct activation of clacium potassium channels.
1-EBIO was used to study the electrical activity modulated by Ca+2-activated K+ channels in rat central neurons. The effect of 1-EBIO on human intermediate conductance channels was studied.
The K+ channel opener 1-EBIO potentiates residual function of mutant CFTR in rectal biopsies from cystic fibrosis patients | [Definition]
ChEBI: 1-Ethyl-2-benzimidazolinone is a member of imidazoles. | [Biological Activity]
Activator of epithelial K Ca channels, stimulates a large and sustained trans-epithelial Cl - secretory response across T84 monolayers. Induces hyperpolarization to the same magnitude as ACh in aortic value endothelial cells. | [storage]
Room temperature | [References]
1) Adeagbo?et al.?(1999),?1-Ethyl-2-benzimidazolinone stimulates endothelial K(Ca) channels and nitric oxide formation in rat mesenteric vessels; Eur. J. Pharmacol.,?379?151
2) Orfila?et al. (2014),?Increasing small conductance Ca2+-activated potassium channel activity reverses ischemia-induced impairment of long-term potentiation; Eur. J. Neurosci.,?40?3179
3) Allen?et al.?(2011),?SK2 channels are neuroprotective for ischemia-induced neuronal cell death; J. Cereb. Blood Flow Metab.,?31?2302
4) Muller?et al. (2012),?Ca2+ activated K channels-new tools to induce cardiac commitment from pluripotent stem cells in mice and men; Stem Cell Rev.,?8?720
5) Fay?et al.?(2006),?SK channels mediate NADPH oxidase-independent reactive oxygen species production and apoptosis in granulocytes; Proc. Natl. Acad. Sci. USA,?103?17548 |
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
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