| Identification | Back Directory | [Name]
CMP-NAN SODIUM SALT | [CAS]
1007117-62-5 | [Synonyms]
CMP-NAN SODIUM SALT
CMP-NANA SODIUM SALT
CMP-SIALIC ACID SODIUM SALT
CYTIDINE 5'-MONOPHOSPHO-N-ACETYLNEURAMINIC ACID SODIUM SALT
sodium:(2R,4S,5R,6R)-5-acetamido-2-[[(2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate | [Molecular Formula]
C20H30N4NaO16P | [MDL Number]
MFCD00151579 | [MOL File]
1007117-62-5.mol | [Molecular Weight]
636.43 |
| Chemical Properties | Back Directory | [storage temp. ]
−20°C
| [solubility ]
PBS (pH 7.2): 10 mg/ml | [form ]
A crystalline solid | [color ]
White to off-white | [biological source]
synthetic (organic) |
| Hazard Information | Back Directory | [Description]
CMP-Sialic acid is a form of the sugar N-acetylneuraminic acid (Neu5Ac) O-linked with the nucleotide cytidine-5’-monophosphate (CMP). In vertebrates, it is biosynthesized within the nucleus from CTP and Neu5Ac by CMP-sialic acid synthetases. Sialyltransferases transfer Neu5Ac from CMP-sialic acid to various acceptor substrates, most commonly at terminal positions of the oligosaccharide component of glycoproteins or glycolipids. Sialic acid-containing glycans at the cell surface play important roles in cell interactions and have roles in infection, inflammation, and cancer. | [Uses]
CMP-N-acetylneuraminic acid sodium salt is a nucleotide and CMP-?sialic acid derivative used as a building block used in the preparation of N-?glycan microarrays. | [IC 50]
Human Endogenous Metabolite | [storage]
Store at -20°C | [References]
[1] ANJA K MüNSTER-KüHNEL. Structure and function of vertebrate CMP-sialic acid synthetases.[J]. Glycobiology, 2004, 14 10: 43R-51R. DOI: 10.1093/glycob/cwh113
[2] TSUJI S. Molecular cloning and functional analysis of sialyltransferases.[J]. Journal of biochemistry, 1996, 120 1: 1-13. DOI: 10.1093/oxfordjournals.jbchem.a021369
[3] MAGALI AUDRY. Current trends in the structure-activity relationships of sialyltransferases.[J]. Glycobiology, 2011, 21 6: 716-726. DOI: 10.1093/glycob/cwq189
[4] HENNET T. From glycosylation disorders back to glycosylation: What have we learned?[J]. Biochimica et biophysica acta. Molecular basis of disease, 2009, 1792 9: Pages 921-924. DOI: 10.1016/j.bbadis.2008.10.006
[5] ANNIE N SAMRAJ. Involvement of a non-human sialic Acid in human cancer.[J]. Frontiers in Oncology, 2014: 33. DOI: 10.3389/fonc.2014.00033 |
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BOC Sciences
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