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1007386-15-3

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1007386-15-3 Structure

1007386-15-3 Structure
IdentificationBack Directory
[Name]

m-PEG6-SS-PEG6-methyl
[CAS]

1007386-15-3
[Synonyms]

m-PEG6-SS-PEG6-methyl
[Molecular Formula]

C26H54O12S2
[MDL Number]

MFCD32207020
[MOL File]

1007386-15-3.mol
[Molecular Weight]

622.83
Chemical PropertiesBack Directory
[Boiling point ]

625.9±55.0 °C(Predicted)
[density ]

1.108±0.06 g/cm3(Predicted)
Hazard InformationBack Directory
[Description]

m-PEG6-SS-PEG6-methyl contains two terminal methoxy groups and a cleavable disulfide bond. The disulfide bond can be cleaved via reduction reactions using Dithiothreitol (DTT) reagent.
[Uses]

m-PEG6-SS-PEG6-methyl is a cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
[IC 50]

Disulfide Cleavable Linker; Cleavable Linker
[References]

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268
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