| Identification | Back Directory | [Name]
2,5,8,11,14,17,20,23-Octaoxapentacosane-25-thiol | [CAS]
651042-83-0 | [Synonyms]
MPEG8-SH
m-PEG8-Thiol
2,5,8,11,14,17,20,23-Octoxapentacosane-25-thiol
2,5,8,11,14,17,20,23-Octaoxapentacosane-25-thiol
2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanethiol | [Molecular Formula]
C17H36O8S | [MDL Number]
MFCD16619328 | [MOL File]
651042-83-0.mol | [Molecular Weight]
400.53 |
| Chemical Properties | Back Directory | [density ]
1.070 | [form ]
Liquid | [color ]
Colorless to light yellow | [InChI]
InChI=1S/C17H36O8S/c1-18-2-3-19-4-5-20-6-7-21-8-9-22-10-11-23-12-13-24-14-15-25-16-17-26/h26H,2-17H2,1H3 | [InChIKey]
LWTPDVASPXFETP-UHFFFAOYSA-N | [SMILES]
COCCOCCOCCOCCOCCOCCOCCOCCS |
| Hazard Information | Back Directory | [Description]
m-PEG8-thiol is a PEG linker containing a thiol group. The thiol group reacts with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc. The hydrophilic PEG spacer increases solubility in aqueous media. | [Uses]
m-PEG8-thiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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