| Identification | Back Directory | [Name]
MK-5108 (VX-689) | [CAS]
1010085-13-8 | [Synonyms]
VX-689
CS-545
MK-5198
MK-5108
MK-5108(VX-689)
MK-5108 (VX-689) USP/EP/BP
MK 5108; VX-689; VX 689; MK5108; VX689
trans-4-(3-Chloro-2-fluorophenoxy)-1-[[6-(2-thiazolylamino)-2-pyridinyl]methyl]cyclohexanecarboxylic acid
(1r,4r)-4-(3-chloro-2-fluorophenoxy)-1-((6-(thiazol-2-ylaMino)pyridin-2-yl)Methyl)cyclohexanecarboxylic acid
Cyclohexanecarboxylic acid, 4-(3-chloro-2-fluorophenoxy)-1-[[6-(2-thiazolylamino)-2-pyridinyl]methyl]-, trans- | [Molecular Formula]
C22H21ClFN3O3S | [MDL Number]
MFCD22124479 | [MOL File]
1010085-13-8.mol | [Molecular Weight]
461.94 |
| Chemical Properties | Back Directory | [Boiling point ]
637.6±65.0 °C(Predicted) | [density ]
1.429 | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [solubility ]
≥23.1 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O | [form ]
solid | [pka]
4.41±0.44(Predicted) | [color ]
White to off-white | [InChIKey]
LCVIRAZGMYMNNT-VVONHTQRSA-N | [SMILES]
[C@]1(CC2=NC(NC3=NC=CS3)=CC=C2)(C(O)=O)CC[C@@H](OC2=CC=CC(Cl)=C2F)CC1 |
| Hazard Information | Back Directory | [Uses]
MK-5108 is a highly selective Aurora-A kinase inhibitor that shows antitumor activity alone and in combination with Docetaxel (D494420). | [Definition]
ChEBI: 4-(3-chloro-2-fluorophenoxy)-1-[[6-(2-thiazolylamino)-2-pyridinyl]methyl]-1-cyclohexanecarboxylic acid is an aromatic ether. | [Biological Activity]
mk-5108, also known as vx-689, is a novel, potent and selective inhibitor of aurora a kinase (aak) that competitively binds to the atp binding site of aak and hence potently inhibits the activity of aak with 50% inhibition concentration ic50 value of 0.064 nm. mk-5108 also inhibits other members of aurora kinase family, including aurora b kinase (ic50 = 14 nm) and aurora c kinase (ic50 = 12 nm), with a lesser potency. mk-5108 has been extensively studies and found to exhibit antitumor activity in a wide range of cancer types, including breast, cervix, colorectal, ovary and pancreas neoplasms.myke r. green, bs, pharm.d., bcop, joseph e. woolery, bs, pharm.d, and daruka mahadevan, md, phd. update on aurora kinase targeted therapeutics in oncology. recent pat anticancer drug discov. 2008 november ; 3(3): 162–177. | [in vivo]
MK-5108 treatments at 15 and 30 mg/kg results in significant tumor growth inhibition in the HCT116 tumor model. MK-5108 is well tolerated at both doses, with minimal reduction in body weight. MK-5108 also exhibits significant antitumor activity in nude rats bearing SW48 tumors. MK-5108 at 15 and 45 mg/kg causes dose-dependent tumor growth inhibition with a %T/C of 35% and 7% at day 10, and 58% and 32% at day 27, respectively. MK-5108 is well tolerated in nude rats, with no body weight reduction and moderate effect on blood cells[1]. | [target]
Aurora-A | [IC 50]
Aurora A: 64 pM (IC50) |
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| Company Name: |
NCE Biomedical Co.,Ltd.
|
| Telephone: |
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15748/0_EN.htm |
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