| Identification | Back Directory | [Name]
CC-885 | [CAS]
1010100-07-8 | [Synonyms]
CC-885
1-(3-Chloro-4-methylphenyl)-3-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)urea
Urea, N-(3-chloro-4-methylphenyl)-N'-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-5-yl]methyl]- | [Molecular Formula]
C22H21ClN4O4 | [MDL Number]
MFCD31657329 | [MOL File]
1010100-07-8.mol | [Molecular Weight]
440.88 |
| Chemical Properties | Back Directory | [solubility ]
DMSO:40.0(Max Conc. mg/mL);90.72(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.45(Max Conc. mM)
DMF:12.5(Max Conc. mg/mL);28.35(Max Conc. mM) | [form ]
A crystalline solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
CC-885 is a potent Cereblon Modulator with potent antitumor activity mediated through the degradation of GSPT1. was demonstrated to mediate antitumor effects through the recruitment and degradation of G1 to S phase transition 1 protein (GSPT1). GSPT1 (also named eRF3a) is a translation termination factor that binds eukaryotic translation termination factor 1 (eFR1) to mediate stop codon recognition and nascent protein release from the ribosome. | [Uses]
CC-885 is a cereblon (CRBN) modulator with potent anti-tumour activity. CC-885 is also a known degrader of GSPT1, inhibiting protein translation. | [target]
CC-885 is a cereblon (CRBN) modulator. | [IC 50]
Cereblon | [References]
[1] Mary E. Matyskiela, et al. A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase. Nature. 2016 Jul 14;535(7611):252-7. DOI:10.1038/nature18611
[2] Jochem M, et al. Degradome analysis to identify direct protein substrates of small-molecule degraders[J]. bioRxiv, 2024: 2024.01. 28.577572. |
|
|