| Identification | Back Directory | [Name]
CC-92480 | [CAS]
2259648-80-9 | [Synonyms]
CC92489
CC-92480
Benzonitrile, 4-[4-[[4-[[[2-[(3S)-2,6-dioxo-3-piperidinyl]-2,3-dihydro-1-oxo-1H-isoindol-4-yl]oxy]methyl]phenyl]methyl]-1-piperazinyl]-3-fluoro- | [Molecular Formula]
C32H30FN5O4 | [MOL File]
2259648-80-9.mol | [Molecular Weight]
567.61 |
| Chemical Properties | Back Directory | [Boiling point ]
833.0±65.0 °C(Predicted) | [density ]
1.41±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: soluble | [form ]
A solid | [pka]
10.70±0.40(Predicted) | [color ]
White to off-white | [InChIKey]
YTINZZFBHWSAGL-NDEPHWFRSA-N | [SMILES]
C(#N)C1=CC=C(N2CCN(CC3=CC=C(COC4=CC=CC5=C4CN([C@H]4CCC(=O)NC4=O)C5=O)C=C3)CC2)C(F)=C1 |
| Hazard Information | Back Directory | [Uses]
Mezigdomide (CC-92480), a cereblon E3 ubiquitin ligase modulating agent (CELMoD), acts as a molecular glue. Mezigdomide shows high affinity to cereblon, resulting in potent antimyeloma activity[1]. | [References]
[1] Nooka AK, et al. Mechanism of Action and Novel IMiD-Based Compounds and Combinations in Multiple Myeloma. Cancer J. 2019 Jan/Feb;25(1):19-31. DOI:10.1097/PPO.0000000000000354 |
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| Company Name: |
ChemCell Biomedicine Co.,Ltd.
|
| Telephone: |
020-13556033878 2965585218 13556033878 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList15061/0_EN.htm |
| Company Name: |
TOSUN PHARM
|
| Telephone: |
020-66392521-118 18922260391 |
| Website: |
www.toref.cn/ |
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