| Identification | More | [Name]
NITRIC OXIDE | [CAS]
10102-43-9 | [Synonyms]
NITRIC OXIDE
NITROGEN MONOXIDE
Amidogen, oxo-
bioxyded’azote
bioxyded’azote(french)
mononitrogenmonoxide
nitric
nitricoxide0
nitricoxidetrimer
Nitrogenoxide(Nitricoxide)
nitrogenoxide(no)
Nitrosyl radical
nitrosylradical
NO
oxo-amidoge
oxydenitrique
oxydenitrique(french)
rcrawastenumberp076
stickmonoxyd
Stickstoff(II)-oxid | [EINECS(EC#)]
233-271-0 | [Molecular Formula]
NO * | [MDL Number]
MFCD00011525 | [Molecular Weight]
30.01 | [MOL File]
10102-43-9.mol |
| Chemical Properties | Back Directory | [Appearance]
Nitric oxide is a colorless gas with a sharp, sweet
odor; brown at high concentration in air. Shipped as a nonliquefied
compressed gas. | [Melting point ]
−163.6 °C(lit.)
| [Boiling point ]
−151.7 °C(lit.)
| [density ]
d-150.2 (liq) 1.27; Relative d (gas) 1.036 (air = 1); Absolute d (gas) 1.227 (air = 1) | [vapor density ]
1.05 (vs air)
| [refractive index ]
nD25 1.0002697 | [solubility ]
At 20 °C and at a pressure of 101 kPa, 1 volume dissolves in about 21 volumes of water. | [form ]
colorless gas | [color ]
colorless | [Stability:]
Spontaneously reacts with oxygen in air to yield brown nitrogen dioxide. Reacts violently or explosively with ammonia and many organic materials. | [Water Solubility ]
slightly soluble H2O [HAW93] | [Merck ]
13,6611 | [Exposure limits]
TLV-TWA 25 ppm (～30 mg/m3) (ACGIH,
MSHA, and OSHA). | [InChIKey]
MWUXSHHQAYIFBG-UHFFFAOYSA-N | [CAS DataBase Reference]
10102-43-9(CAS DataBase Reference) | [EPA Substance Registry System]
Nitric oxide (10102-43-9) |
| Questions And Answer | Back Directory | [Uses]
Nitric oxide is an important intermediate in the production of nitric acid. Fluorine, chlorine, and bromine react with nitric oxide to form the corresponding nitrosyl halide. [t is also used in making mixtures for calibration standards for stationary and mobile exhaust emission measurements. |
| Hazard Information | Back Directory | [Chemical Properties]
Nitric oxide is a colorless gas with a sharp, sweet
odor; brown at high concentration in air. Shipped as a nonliquefied
compressed gas. | [Chemical Properties]
Nitric oxide,NO, also known as nitrogen oxide and nitrogen monoxide, is a colorless gas that will react with oxygen at room temperature to form nitrogen dioxide, N202, a reddish-brown gas.It is soluble in water and alcohol and is used primarily to form other compounds.
| [Definition]
ChEBI: Nitric Oxide is a nitrogen oxide which is a free radical, each molecule of which consists of one nitrogen and one oxygen atom.
| [General Description]
A colorless gas. Noncombustible but accelerates the burning of combustible material. Vapors heavier than air. Very toxic by inhalation and skin absorption. Heating the containers may cause them to rupture violently and rocket. | [Reactivity Profile]
NITRIC OXIDE can serve as both an oxidizing agent and as a reducing agent. Sustains the combustion of powdered aluminum [Mellor 5:209-212. 1946-47]. Enflames or explodes when mixed with vapors of carbon disulfide [Mellor 8, Supp. 2:232. 1967]. Reacts vigorously with sodium monoxide above 100°C [Mellor 2, Supp. 2:629. 1961]. Reacts on contact with oxygen at room temperature to form brown gaseous nitrogen dioxide. Reacts with alkalis to form nitrates and nitrites [Merck 11th ed. 1989]. The liquid is very sensitive to detonation in the presence of water. | [Air & Water Reactions]
Combines very rapidly with oxygen in the air to form nitrogen dioxide. Nitrogen dioxide reacts with water to form nitric acid and NITRIC OXIDE(10102-43-9), reacts with alkalis to form nitrates and nitrites [Merck 11th ed. 1989]. | [Hazard]
Supports combustion. Toxic by inhalation,
strong irritant to skin and mucous membranes.
Hypoxia/cyanosis, nitrosyl-hemoglobin formation,
and upper respiratory tract irritant. | [Health Hazard]
Can cause death or permanent injury after a very short exposure to small quantities. Irritant of eyes, nose, throat; can cause unconsciousness. Nitric oxide forms acids in the respiratory system which are irritating and cause congestion in the lungs. Concentrations of 60-150 ppm cause immediate irritation of the nose and throat with coughing and burning in the throat and chest. 6-24 hours after exposure, labored breathing and unconsciousness may result. Concentrations of 100-150 ppm are dangerous for short exposure of 30-60 minutes. Concentrations of 200-700 ppm may be fatal after very short exposure. | [Potential Exposure]
Nitric oxide is used in the manufacture
of nitric acid; it is also used in the bleaching of rayon;
it is a raw material for nitrosyl halide preparation. | [First aid]
If this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek
medical attention immediately. If this chemical contacts the
skin, remove contaminated clothing and wash immediately
with soap and water. Seek medical attention immediately.
If this chemical has been inhaled, remove from exposure,
begin rescue breathing (using universal precautions, including
resuscitation mask) if breathing has stopped and CPR if
heart action has stopped. Transfer promptly to a medical
facility. When this chemical has been swallowed, get medical
attention. Give large quantities of water and induce
vomiting. Do not make an unconscious person vomit.
Effects may be delayed; keep victim under observation.
Medical observation is recommended for 24 48 hours after
breathing overexposure, as pulmonary edema may be
delayed. As first aid for pulmonary edema, a doctor or
authorized paramedic may consider administering a drug or
other inhalation therapy. | [Shipping]
UN1660/124 Nitric oxide, compressed, Hazard
Class: 2.3; Labels: 2.3-Poisonous gas, 5.1-Oxidizer,
8-Corrosive material, Inhalation Hazard Zone A. Cylinders
must be transported in a secure upright position, in a wellventilated
truck. Protect cylinder and labels from physical
damage. The owner of the compressed gas cylinder is the
only entity allowed by federal law (49CFR) to transport
and refill them. It is a violation of transportation regulations
to refill compressed gas cylinders without the express
written permission of the owner. | [Incompatibilities]
A strong oxidizer but may also act as a
reducing agent. Explosive reaction with nitrogen
trichloride, ozone, carbon disulfide; pentacarbonyl iron;
chlorine monoxide. Incompatible with halogens, combustibles,
metals, oil, alcohols, chlorinated hydrocarbons (e.g.,
trichloroethylene), reducing agents (such as NH3), oxygen,
fluorine, metals. Reacts with water to form nitric acid.
Rapidly converted in air to nitrogen dioxide. Combines
very rapidly with oxygen in the air to form nitrogen dioxide.
Nitrogen dioxide reacts with water to form nitric acid
and nitric oxide, reacts with alkalis to form nitrates and
nitrites. | [Description]
near room temperature (its liquid density at 20°C is 1.45 g/cm3).
Nitrogen monoxide (NO) is commonly called nitric oxide,Nitric oxide is colorless and has a sharp sweet odor;Nitric oxide is nonfl ammable, toxic gases.Nitric oxide is a free radical that quickly reacts in air to produce nitrogen dioxide.It is also an
important biological messenger and transmitter. | [Waste Disposal]
Return refillable compressed
gas cylinders to supplier. Incineration with added hydrocarbon
fuel, controlled so as to produce elemental nitrogen,
CO2, and water. Consult with environmental regulatory
agencies for guidance on acceptable disposal practices.
Generators of waste containing this contaminant (≥100 kg/
mo) must conform with EPA regulations governing storage,
transportation, treatment, and waste disposal. | [Physical properties]
Colorless gas; paramagnetic; density 1.3402 g/L; slightly heavier than air, air density 1.04 (air=1); liquefies at -151.8°C to a blue liquid; the refractive index of the liquid 1.330 at -90°C; the density of the liquid 1.269 g/mL at -150.2°C; solidifies at -163.6°C to a bluish-white snow-like solid; critical temperature -94°C; critical pressure 65 atm; slightly soluble in water, 4.6 mL gas dissolves in 100 mL water at 20°C while 7.34 mL and 2.37 mL dissolve in the same volume of water at 0 and 60°C, respectively; more soluble in alcohol than water; soluble in carbon disulfide, and in ferrous sulfate solution (reacts). | [History]
Nitric oxide was prepared in 1772 by Joseph Priestley
(1733–1804) and described in his volumes Experiments and Observations of Different Kinds
of Air published between 1774 and 1786. Priestley called nitric oxide nitrous air, nitrogen
dioxide nitrous acid vapor, and nitrous oxide phlogisticated nitrous air, but also referred to the
latter as diminished nitrous air. He observed the change of clear nitric oxide to red nitrogen
dioxide. Priestley prepared nitric oxide by reacting nitric acid with a metal such as copper:
3Cu(s) + 8HNO3(aq) → 2NO(g) + 3Cu(NO3)2(aq) + 4H2O(l). | [Production Methods]
Nitric oxide is commercially produced by the catalytic oxidation of ammonia using aplatinum catalyst: 4NH3(g) + 5O2(g) → 4NO(g) + 6H2O(g). | [Biological Functions]
Nitric oxide is a small, unstable free radical that acts as a
biological messenger in many physiological responses.
Because it can diffuse freely in all directions from its site
of origin, regulation of the activity of nitric oxide is primarily
through control of its synthesis. Formation of nitric
oxide occurs through oxidation of the amino acid Larginine,
a reaction catalyzed by the enzyme nitric oxide
synthase (NOS), to produce nitric oxide and L-citrulline.
The forms of NOS differ in their cellular location and
expression (constitutive expression versus inducible expression).
Activation of synthesis of the inducible form of NOS results in continued synthesis of nitric oxide for
several hours. Inhibitors of NOS are analogues of arginine,
including L-Nw nitroarginine (L- NNA) and L-Nw
methylarginine (L-NMA), both of which decrease nitric
oxide synthesis.
Physiological sites proposed for nitric oxide action
include the immune system, where nitric oxide acts as a
cytostatic agent, is tumoricidal, and can inhibit viral
replication. In the cardiovascular system, nitric oxide is
the biological mediator of vasodilator responses to
agents such as acetylcholine and bradykinin, which act
as receptors on endothelial cells to activate NOS and
stimulate nitric oxide production. Diffusible nitric oxide
then activates guanylate cyclase in vascular smooth
muscle cells, leading to the production of cyclic guanosine
monophosphate (GMP) and vasodilation. In the
brain, stimulation of N-methyl-D-aspartate receptors on neurons leads to activation of the brain form of NOS
and stimulates production of nitric oxide. The function
of brain nitric oxide is thought to involve actions as
a retrograde neurotransmitter whereby nitric oxide
diffuses back to the presynaptic neuron to activate
guanylate cyclase and increase cyclic GMP levels.
Through these retrograde actions nitric oxide is thought
to play a role in the neural circuitry involved in memory.
Even though nitric oxide is the physiological mediator
of a variety of responses, excess nitric oxide is toxic to
many cells as a result of its role in the production of peroxynitrite
and resultant lipid oxidation. Inhibitors of the
NOS enzyme are in clinical trials for the treatment of hypotension
associated with septic shock. Administration
of low concentrations of nitric oxide through respiratory
ventilators has been implemented to treat persistent pulmonary
hypertension of the newborn. | [Purification Methods]
Bubble the gas through 10M NaOH which removes NO2. It can also be freed from NO2 by passage through a column of Ascarite followed by a column of silica gel held at -197oK. The gas is dried with solid NaOH pellets or by passing through silica gel cooled at -78o, followed by fractional distillation from a liquid N2 trap. This purification does not eliminate nitrous oxide. Other gas scrubbers sometimes used include one containing conc H2SO4 and another containing mercury. It is freed from traces of N2 by the freeze and thaw method. [Blanchard Inorg Synth II 126 1946, Schenk in Handbook of Preparative Inorganic Chemistry (Ed. Brauer) Academic Press Vol I pp 485-487 1963.] TOXIC. | [Fire Hazard]
Noncombustible gas; burns with fuels,
hydrocarbons, or when heated with hydrogen.
Nitric oxide reacts violently with carbon
disulfide vapors, producing green luminous
flame; with fluorine, it produces a pale yel low flame. It explodes when mixed with
ozone, chlorine monoxide, or a nitrogen tri halide. Reactions with many pyrophoric met als produce incandescence. Reaction with
amorphous boron produces brilliant flashes. | [Materials Uses]
Nitric oxide is noncorrosive, and most common
structural materials may be used. However, in
the presence of moisture and oxygen, corrosive
conditions will develop as a result of the formation
of nitric and nitrous acids. Prior to use,
systems to contain nitric oxide must first be
purged with an inert gas. Where air contamination
cannot be eliminated, stainless steel should
be used. | [Physiological effects]
Nitric oxide with the attendant formation of
nitrogen dioxide results in a strong respiratory
irritant that may be fatal. Symptoms may be
moderate at first and include tightness in the
chest, headaches, irritation of the eyes, nausea,
and a slow loss of strength. Delayed symptoms
may be severe and cause increased difficulty in
breathing, chemical pneumonitis, and pulmonary
edema. Untreated cases could lead to
eventual death. Exposure to 100 ppm to 150
ppm of nitrogen oxides for 30-60 minutes could
lead to delayed pulmonary edema, and a few
breaths of nitrogen oxides in 200 ppm to 700
ppm concentrations may result in fatal pulmonary
edema after 5-8 hours have passed.
Acute exposure to nitric oxide alone at high
levels results in the rapid formation of methemog[
obin. Nitric oxide itself does not have the
marked irritant effect of nitrogen dioxide. However,
due to the rapid formation of methemoglobin,
greater lethality can be associated with
high acute levels of exposure to nitric oxide
than with nitrogen dioxide exposures. Initial
symptoms such as muscular tremors, drowsiness,
a brownish-blue hue to the mucous membranes,
increased heart and respiratory rate,
vertigo, and vomiting can occur at methemoglobin
levels of 30 percent to 40 percent. Coma
and death can ensue when methemoglobin levels
reach 70 percent to 90 percent.
ACGIH recommends the Threshold Limit
Value-Time-Weighted Average (TLV-TWA)
of 25 ppm (31 mg/m3
) for nitric oxide. The
TLV-TWA is the time-weighted average concentration
for a normal 8-hour workday and a
40-hour workweek, to which nearly all workers
may be repeatedly exposed, day after day, without
adverse effect.
OSHA lists the 8-hour Time-Weighted Average-
Permissiable Exposure Limit (TWA-PEL)
of 25 ppm (30 mg/m3
) for nitric oxide. TWAPEL
is the exposure limit that shall not be exceeded
by the 8-hour TWA in any 8-hour work
shift of a 40-hour workweek. At normal ambient
temperatures, nitric oxide combines with
atmospheric oxygen to form nitrogen dioxide at
a rate dependent on the concentration of oxygen
and the square of the concentration of nitric
oxide. | [Environmental Fate]
Nitric oxide is converted spontaneously in the air to nitrogen
dioxide; hence, some of the latter gas is present whenever nitric
oxide is found in air (at concentrations below 50 ppm). Nitric
oxide is a contributor to photochemical air pollution. | [storage]
Nitric oxide should only be used in
well-ventilated areas. Valve protection caps and
valve outlet threaded plugs must remain in place
unless the container is secured and the valve
outlet piped to the point of use. Do not drag,
slide, or roll cylinders. Use a suitable hand truck
to move cylinders. Use a pressure reducing
regulator when connecting a cylinder to lower
pressure (1000 psig or 6900 kPa) piping systems.
Do not heat a cylinder of nitric oxide by
any means to increase the discharge rate from
the cylinder. Use a check valve or trap in the
discharge line to prevent hazardous reverse flow
into the cylinder. | [Toxicity evaluation]
A cytotoxic free radical, nitric oxide impairs mitochondrial ATP
synthesis by inhibiting the citrate cycle and other cellular
mechanisms of electron transport. | [GRADES AVAILABLE]
Nitric oxide is available in a minimum purity of
98.5 percent or 99.0 percent. |
| Safety Data | Back Directory | [Hazard Codes ]
O,T | [Risk Statements ]
R8:Contact with combustible material may cause fire.
R23:Toxic by inhalation.
R34:Causes burns.
R44:Risk of explosion if heated under confinement. | [Safety Statements ]
S17:Keep away from combustible material .
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 1660 2.3
| [WGK Germany ]
1
| [RTECS ]
QX0525000
| [DOT Classification]
2.3, Hazard Zone A (Gas poisonous by inhalation) | [HazardClass ]
2.3 | [Safety Profile]
A poison gas. A severe
eye, skin, and mucous membrane irritant. A
systemic irritant by inhalation. Mutation data
reported. Exposure may occur whenever
nitric acid acts upon organic material, such
as wood, sawdust, and refuse; it occurs
when nitric acid is heated, and when organic
nitro compounds are burned, for example,
celluloid, cellulose nitrate (guncotton), and
dynamite. The action of nitric acid upon
metals, as in metal etchng and pickling, also
liberates the fumes. In hgh-temperature
weldmg, as with the oxyacetylene or electric
torch, the nitrogen and oxygen of the air
unite to form oxides of nitrogen.
Automobile exhaust and power plant
emissions are also sources of NOx.
Exposure occurs in many manufacturing nitric and nitrous acids. This is the action
that takes place deep in the respiratory
system. The acids formed are irritating and
can cause congestion in the throat and
bronchi and edema of the lungs. The acids
are neutralized by the alkalies present in the
tissues, with the formation of nitrates and
nitrites. The latter may cause some arterial
ddation, fall in blood pressure, headache,
and dizziness, and there may be some
formation of methemoglobin. However, the
nitrite effect is of secondary importance.
Because of their relatively low solubllity in
water, the nitrogen oxides are initially only
slightly irritating to the mucous membranes
of the upper respiratory tract. Their warning
power is therefore low, and dangerous
amounts of the fumes may be breathed
before the worker notices any real
discomfort. Higher concentrations (60-150
ppm) cause immediate irritation of the nose
and throat, with coughing and burning in
the throat and chest. These symptoms often
clear upon breathing fresh air, and the
worker may feel well for several hours.
Some 6-24 hours after exposure, a sensation
of tightness and burning in the chest
develops, followed by shortness of breath,
sleeplessness, and restlessness. Dyspnea and
air hunger may increase rapidly with
development of cyanosis and loss of
consciousness followed by death. In cases
that recover from the pulmonary edema,
there is usually no permanent disabiltty, but
pneumonia may develop later.
Concentrations of 100-150 ppm are
dangerous for short exposures of 30-60
minutes. Concentrations of 200-700 ppm
may be fatal after even very short exposures.
Continued exposure to low concentrations
of the fumes, insufficient to cause
pulmonary edema, is said to result in chronic
irritation of the respiratory tract, with cough,
headache, loss of appetite, dyspepsia,
corrosion of the teeth, and gradual loss of
strength.
Exposure to NOx is always potentially
serious, and persons so exposed should be hours.
An oxidizer. The liquid is a sensitive
explosive. Explosive reaction with carbon
disulfide (when ignited), methanol (when
ignited), pentacarbonyl iron (at 50℃),
phosphine + oxygen, sodium diphenylketyl,
dichlorine oxide, fluorine, nitrogen
trichloride, ozone, perchloryl fluoride (at
100-300°C), vinyl chloride. Reacts to form
explosive products with dienes (e.g., 1,3-
butadiene, cyclopentadiene, propadiene).
Can react violently with acetic anhydride,
Al, amorphous boron, BaO, BCl3, CsHC2,
calcium, carbon + potassium hydrogen
tartrate, charcoal, Cl0, pyrophoric
chromium, 1,2-dichloroethane,
dichloroethylene, ethylene, fuels,
hydrocarbons, hydrogen + oxygen, NasO,
uns-dimethyl hydrazine, NH3, CHCl3, Fe,
Mg, Mn, CH2Cl2, olefins, phosphorus,
PNH2, PH3, potassium, potassium sulfide,
propylene, rubidum acetylide, Na, S,
tungsten carbide, trichloroethylene, 1,1,1-
trichloroethane, uns-tetrachloroethane,
uranium, uranium dicarbide. Wdl react with
water or steam to produce heat and
corrosive fumes; can react vigorously with
reducing materials.
processes when nitric acid is made or used.
Oxides of nitrogen have been implicated as
a cause of acid rain.
The oxides of nitrogen are somewhat
soluble in water, reacting with it to form | [Hazardous Substances Data]
10102-43-9(Hazardous Substances Data) | [Toxicity]
LCLo inhalation in dog: 5000ppm/25M | [IDLA]
100 ppm |
| Questions and Answers (Q&A) | Back Directory | [Uses]
Industry
Application
Role/benefit
Chemical manufacture
Manufacture of nitric acid
Intermediate
Manufacture of hydroxylamine
Intermediate
Medcine
Treatment of primary pulmonary hypertension
Active ingredient/helps to promote capillary and pulmonary dilation
Treatment of respiratory failure in premature babies
Active ingredient/can relax smooth muscle to widen (dilate) blood vessels
Treatment of impotence or erectile dysfunction
Active ingredient/enhances nitric oxide’s relaxant effects on smooth muscle cells in the corpus cavernosa
Chemical analysis
Detecting surface radicals on polymers
Radicals quenching agent
Analysis for nitric acid or its salts
Analytical agent
Others
Narcotics and preservatives
Effective component
Rayon production
Decolorizer
Propylene and dimethyl ether preservation
Stabilizing agent
Semiconductor manufacturing
Oxidation and chemical vapor deposition gas
| [References]
1.https://en.wikipedia.org/wiki/Nitric_oxide
2.https://www.drugs.com/mtm/nitric-oxide-inhalation-gas.html
3.https://www.britannica.com/science/nitric-oxide
4.http://pediatrics.aappublications.org/content/106/2/344
5.http://www.mensfitness.com/nutrition/supplements/supplement-guide-nitric-oxide
6.https://www.chemicalbook.com/ProductChemicalPropertiesCB5433122.htm
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