| Identification | Back Directory | [Name]
Biotin-PEG2-C6-Azide | [CAS]
1011268-29-3 | [Synonyms]
Biotin-PEG2-C6-Azide
Biotin-PEG8-C6-Azide | [Molecular Formula]
C22H39N7O5S | [MDL Number]
MFCD28505538 | [MOL File]
1011268-29-3.mol | [Molecular Weight]
513.66 |
| Hazard Information | Back Directory | [Description]
Biotin-PEG2-C6-azide is PEG linker containing a biotin group and an azide group. The azide group can react with either alkyne moiety in Cu(I)-catalyzed Click Chemistry reaction or DBCO moiety in copper-free Click Chemistry reaction to form a stable triazole linkage. The spacer arm helps to minimize steric hindrance involved with the binding to avidin molecules. | [Uses]
Biotin-PEG2-C6-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTAC. Biotin-PEG2-C6-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs |
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