| Identification | Back Directory | [Name]
Tenovin 6 (Hydrochloride) | [CAS]
1011301-29-3 | [Synonyms]
Tenovin-6.HCl
Tenovin-6 HCl, >=98%
Tenovin 6 (Hydrochloride)
N-[[[4-[[5-(Dimethylamino)-1-oxopentyl]amino]phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide hydrochloride (1:1) | [Molecular Formula]
C25H35ClN4O2S | [MOL File]
1011301-29-3.mol | [Molecular Weight]
491.089 |
| Chemical Properties | Back Directory | [Melting point ]
>180°C (dec.) | [storage temp. ]
-20°C Freezer, Under inert atmosphere | [solubility ]
Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly) | [form ]
Solid | [color ]
Yellow |
| Hazard Information | Back Directory | [Uses]
Tenovin-6 Hydrochloride, is a small molecule activator of p53 transcriptional activity. It acts as a potent SIRT1 and SIRT2 inhibitor as well. | [in vivo]
Tenovin-6 Hydrochloride (50 mg/kg, i.p.) inhibits the growth of tumor in mice[1]. | [IC 50]
SIRT2: 10 μM (IC50); SIRT1: 21 μM (IC50); SIRT3: 67 μM (IC50); HDAC8; MDM-2/p53 | [storage]
Store at -20°C |
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| Company Name: |
SPIRO PHARMA
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| Tel: |
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| Website: |
www.spiropharma.com.cn |
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