| Identification | Back Directory | [Name]
1-(4-Hydroxycyclohexyl)-2-[[5-(2-trifluoromethoxyphenyl)-1H-indazol-3-yl]amino]-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide | [CAS]
1012104-68-5 | [Synonyms]
IRAK inhibitor 4
1H-BenziMidazole-5-carboxaMide, 1-(4-hydroxycyclohexyl)-N-(3-Methylbutyl)-2-[[5-[2-(trifluoroMethoxy)phenyl]-1H-indazol-3-yl]aMino]-
1-(4-Hydroxycyclohexyl)-2-[[5-(2-trifluoromethoxyphenyl)-1H-indazol-3-yl]amino]-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide
1-((1R, 4R)-4-Hydroxycyclohexyl)-N-isopentyl-2-(5-(2-(trifluoromethoxy)phenyl)-1H-indazol-3-ylamino)-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide | [Molecular Formula]
C33H35F3N6O3 | [MDL Number]
MFCD22124483 | [MOL File]
1012104-68-5.mol | [Molecular Weight]
620.66 |
| Chemical Properties | Back Directory | [density ]
1.41 | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Powder | [pka]
13.54±0.40(Predicted) | [color ]
Off-white to light brown |
| Hazard Information | Back Directory | [Uses]
IRAK inhibitor 4 is an interleukin-1 receptor associated kinase 4(IRAK4) inhibitor. | [Biological Activity]
irak inhibitor 4 is an inhibitor of interleukin- 1 receptor-associated kinase [1].irak-4 belongs to interleukin-1 receptor-associated kinase, which are key components in the signal transduction pathways. irak-4 is an essential signal transducer downstream of interleukin-1 receptor (il-1r), interleukin-18 receptor (il-18r) and toll-like receptors (tlrs). inhibition of irak-4 can modulate its function, thus toning down inflammatory responses. irak inhibitor 4 is an indazole inhibitor. as inhibitors of irak-4, imidazo[1,2-b]pyridazines and indazoles are used for treatment of some inflammatory, cell proliferative and immune-related disorders [1]. | [in vivo]
IRAK-4-/-?mice exhibit a greatly reduced survival rate following aerosol infection compared with IRAK-4+/+?or IRAK-4+/-?mice. IRAK-4-/- mice show increased bacterial burden in all organs at 15, 30, and 60 d postinfection[1]. MCL1, but not BCL-xL, overrides the therapeutic effects of combinatorial IRAK1/4 inhibitor and ABT-737 therapy in vivo[3]. | [target]
IRAK | [IC 50]
IRAK4 | [References]
[1] zhulun wang, holger wesche, tracey stevens, nigel walker and wen-chen yeh. irak-4 inhibitors for inflammation. current topics in medicinal chemistry. 2009, 9: 724-737. |
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| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
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