| Identification | More | [Name]
6(5H)-Phenanthridone | [CAS]
1015-89-0 | [Synonyms]
2H-BENZ[C]ISOQUINOLIN-1-ONE
6(5H)-PHENANTHRIDINONE
6(5H)-PHENANTHRIDONE
PHENANTHRIDINONE
PHENANTHRIDONE
6(5H)-Phenantridinone
6-Phenanthridinol
6-Phenanthridone
Phenantridone
phenanthridin-6(5H)-one
3,7-DIAMINO-2-METHOXYFLUOREN 98%
6(5H)-PHENANTHRIDINONE 97%
6-PHENANTHRIDINONE
5,6-Dihydrophenanthridin-6-one
5,6-Dihydrophenanthridine-6-one
Benzo[c]quinoline-6(5H)-one | [EINECS(EC#)]
213-804-3 | [Molecular Formula]
C13H9NO | [MDL Number]
MFCD00004988 | [Molecular Weight]
195.22 | [MOL File]
1015-89-0.mol |
| Chemical Properties | Back Directory | [Melting point ]
290-292 °C(lit.) | [Boiling point ]
435 °C | [density ]
1.230±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMF: 1mg/mL; DMF:PBS (pH 7.2) (1:5): 0.16mg/mL | [form ]
powder to crystal | [pka]
13.27±0.20(Predicted) | [color ]
White to Light yellow to Light orange | [Water Solubility ]
Soluble in DMSO (5 mg/ml). Insoluble in water. | [λmax]
338nm(EtOH)(lit.) | [BRN ]
140641 | [InChI]
InChI=1S/C13H9NO/c15-13-11-7-2-1-5-9(11)10-6-3-4-8-12(10)14-13/h1-8H,(H,14,15) | [InChIKey]
RZFVLEJOHSLEFR-UHFFFAOYSA-N | [SMILES]
C1=C2C(NC(=O)C3=C2C=CC=C3)=CC=C1 | [CAS DataBase Reference]
1015-89-0(CAS DataBase Reference) | [NIST Chemistry Reference]
6(5H)-phenanthridinone(1015-89-0) | [EPA Substance Registry System]
1015-89-0(EPA Substance) |
| Safety Data | Back Directory | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [RTECS ]
SG0370000
| [HS Code ]
29337900 | [Storage Class]
11 - Combustible Solids |
| Hazard Information | Back Directory | [Uses]
6(5H)-Phenanthridinone is used as a probe into the role of PARP in cellular response to irradiation. Treatment of cells with 6(5H)-Phenanthridinone and various DNA-damaging agents showed a resistance to apoptosis. It acts as a reactant in the synthesis of 5,6-dihydrophenanthridine sulfonamides, oxidative coupling with diphenylacetylene, direct copper acetate-catalyzed N-cyclopropylation of cyclic amides. It is used as HIV-1 integrase inhibitor. | [Uses]
6-Phenanthridone is a poly(ADP-ribose) polymerase (PARP) inhibitor with immunosuppressive effects. 6-Phenanthridone has been shown to inhibit concanavalin A-induced lymphocyte proliferation. | [Definition]
ChEBI: A member of the class of phenanthridines that is phenanthridine with an oxo substituent at position 6. A poly(ADP-ribose) polymerase (PARP) inhibitor, it has been shown to exhibit immunosuppressive activity. | [Synthesis Reference(s)]
Canadian Journal of Chemistry, 35, p. 180, 1957 DOI: 10.1139/v57-027
Journal of the American Chemical Society, 79, p. 1245, 1957 DOI: 10.1021/ja01562a054 | [General Description]
6-(5H)-Phenanthridinone is an inhibitor of poly(ADP-ribose)polymerase (PARP)-1 activity. The ability of 6-(5H)-phenanthridinone to potentiate the effect of ionizing radiation on tumour cells was evaluated. Action of 6-(5H)-phenanthridinone, one of the most potent PARP inhibitor, on RDM4 murine lymphoma cells in culture was evaluated. | [storage]
Store at -20°C |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
|
| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
| Company Name: |
Shanghai Ennopharm Co., Ltd.
|
| Telephone: |
+86 (21) 6435-5022 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList13640/0_EN.htm |
|