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10159-53-2

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10159-53-2 Structure

10159-53-2 Structure
IdentificationBack Directory
[Name]

phosphoramide mustard
[CAS]

10159-53-2
[Synonyms]

phosphoramide mustard
[Molecular Formula]

C4H11Cl2N2O2P
[MOL File]

10159-53-2.mol
[Molecular Weight]

221.02
Chemical PropertiesBack Directory
[Melting point ]

115 °C
[Boiling point ]

363.5±52.0 °C(Predicted)
[density ]

1.474±0.06 g/cm3(Predicted)
[pka]

0.41±0.50(Predicted)
Hazard InformationBack Directory
[Definition]

ChEBI:Phosphoramide mustard is a nitrogen mustard and a phosphorodiamide.
[Biological Activity]

Phosphoramide mustard is the active metabolite of cyclophosphamide (HY-17420) with antitumor activity. It induces DNA damage.
[in vitro]

Phosphoramide mustard causes cytotoxicity through forming cross-linked DNA adducts which inhibit DNA strand separation during replication.
It (3-6 μM; 48 hours) reduces cell viability in rat spontaneously immortalized granulosa cells ( SIGCs).
Phosphoramide mustard (3-6 μM; 24-48 hours) induces DNA adduct formation and ovarian DNA damage.
It (3-6 μM; 24-48 hours) increases DNA damage responses (DDR) gene mRNA expression levels and DDR proteins.

Cell Viability Assay

Cell Line: SIGCs
Concentration: 0.5 μM, 1 μM, 3 μM, 6 μM
Incubation Time: 48 hours
Result: Reduced ce ll viability at concentrations of 3 μM and higher.

RT-PCR

Cell Line: SIGCs
Concentration: 3 μM, 6 μM
Incubation Time: 24 hours, 48 hours
Result: Increased DDR gene mRNA expression levels.

Western Blot Analysis

< /tr>
Cell Line: SIGCs
Concentration: 3 μM, 6 μM
Incubation Time: 24 hours, 48 hours
Result: Generally increased DDR pro teins.
[target]

DNA Alkylator

Safety DataBack Directory
[Toxicity]

LD50 intraperitoneal in mouse: 184mg/kg
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