| Identification | More | [Name]
Cyclophosphamide monohydrate | [CAS]
6055-19-2 | [Synonyms]
1-(bis(2-chloroethyl)amino)-1-oxo-2-aza-5-oxaphosphoridine
2-[BIS(2-CHLOROETHYL)AMINO]TETRAHYDRO-2H-1,3,2-OXAZAPHOSPHORINE 2-OXIDE
2-[BIS(2-CHLOROETHYL)AMINO]TETRAHYDRO-2H-1,3,2-OXAZAPHOSPHORINE 2-OXIDE HYDRATE
2-[BIS(2-CHLOROETHYL)AMINO]TETRAHYDRO-2H-1,3,2-OXAZAPHOSPHORINE 2-OXIDE MONOHYDRATE
2-(di(2-chloroethyl)amino)-1-oxa-3-aza-2-phosphacyclohexane 2-oxide
bis(2-chloroethyl)phosphoramide cyclic propanolamide ester monohydrate
CPA
CYCLOPHOSPHAMIDE
CYCLOPHOSPHAMIDE HYDRATE
CYCLOPHOSPHAMIDE MONOHYDRATE
CYCLOPHOSPHAMID MONOHYDRATE
CYTOXAN
ENDOXON
N,N-BIS(2-CHLOROETHYL)TETRAHYDRO-2H-1,3,2-OXAZAPHOSPHORIN-2-AMINE-2-OXIDE MONOHYDRATE
n,n-bis(beta-chloroethyl)-n',o-propylenephosphoric acid ester amide monohydrate
TIMTEC-BB SBB003026
(bis(chloro-2-ethyl)amino)-2-tetrahydro-3,4,5,6-oxazaphosphorine-1,3,2-oxide
1-bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridinemonohydrate
2-(bis(2-chloroethyl)amino)-1-oxa-3-aza-2-phosphocyclohexane2-oxidemonohydr
2-(di(2-chloroethyl)amino)-1-oxa-3-aza-2-phosphacyclohexane-2-oxidemonohydra | [EINECS(EC#)]
200-015-4 | [Molecular Formula]
C7H17Cl2N2O3P | [MDL Number]
MFCD00149395 | [Molecular Weight]
279.1 | [MOL File]
6055-19-2.mol |
| Chemical Properties | Back Directory | [Appearance]
White to Off-White Solid | [Melting point ]
49-51 °C (lit.) | [Fp ]
>230 °F
| [storage temp. ]
2-8°C
| [solubility ]
H2O: 0.1 g/mL, clear, colorless
| [form ]
Crystals or Crystalline Powder | [color ]
White to almost white | [Water Solubility ]
40 g/L | [Usage]
It is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity. Th | [Merck ]
14,2747 | [BRN ]
8167897 | [InChIKey]
PWOQRKCAHTVFLB-UHFFFAOYSA-N | [CAS DataBase Reference]
6055-19-2(CAS DataBase Reference) | [IARC]
1 (Vol. 26, Sup 7, 100A) 2012 | [EPA Substance Registry System]
6055-19-2(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
R45:May cause cancer.
R25:Toxic if swallowed.
R61:May cause harm to the unborn child.
R36/37/38:Irritating to eyes, respiratory system and skin .
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S53:Avoid exposure-obtain special instruction before use .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [RIDADR ]
UN 3464 6.1/PG 3
| [WGK Germany ]
3
| [RTECS ]
RP6157750
| [F ]
10 | [HazardClass ]
6.1 | [PackingGroup ]
II | [HS Code ]
29349990 | [Safety Profile]
Confirmed human
carcinogen. Poison by ingestion and
intravenous routes. Experimental
reproductive effects. Mutation data
reported. When heated to decomposition it
emits toxic fumes of Cl-, PO,, and NOx. |
| Hazard Information | Back Directory | [General Description]
Fine white crystalline powder with a slightly bitter taste. Little or no odor. | [Reactivity Profile]
Polymerization can occur at temperatures > 120° F. CYCLOPHOSPHAMIDE MONOHYDRATE reacts with strong oxidizing agents, strong acids and strong bases. Benzyl alcohol increases rate of hydrolysis. | [Air & Water Reactions]
Water soluble. Sensitive to moisture and light. Aqueous solutions may be kept for a few hours above room temperature, but hydrolysis occurs at temperatures above 86°F. CYCLOPHOSPHAMIDE MONOHYDRATE(6055-19-2) undergoes both specific acid and specific base catalysis at extreme pHs. Spontaneous hydrolysis in aqueous solutions. | [Fire Hazard]
This chemical is probably combustible. | [Chemical Properties]
White to Off-White Solid | [Uses]
alkylating agent in cancer therapy | [Uses]
An immunosuppressive, cytotoxic apoptosis inducer. | [Uses]
antineoplastic, alkylating agent | [Uses]
It is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity. This substance is listed as a known human carcinogen. | [Definition]
ChEBI: The monohydrate of cyclophosphamide. | [Brand name]
Cytoxan (Bristol-Myers Squibb); Neosar (Sicor). | [Biochem/physiol Actions]
Cyclophosphamide is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity. |
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