| Hazard Information | Back Directory | [Uses]
NSC 80467, a DNA damaging agent, selectively inhibits survivin. NSC 80467 preferentially inhibits DNA synthesis and results in induction of γH2AX and pKAP1, two markers of DNA damage[1]. | [References]
[1] Glaros TG, et al. The "survivin suppressants" NSC 80467 and YM155 induce a DNA damage response [published correction appears in Cancer Chemother Pharmacol. 2012 Nov;70(5):763-4]. Cancer Chemother Pharmacol. 2012;70(1):207-212. DOI:10.1007/s00280-012-1868-0 |
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