| Identification | More | [Name]
PHENYLBIGUANIDE | [CAS]
102-02-3 | [Synonyms]
1-PHENYLBIGUANIDE
N-PHENYLIMINODICARBONIMIDIC-DIAMIDE
PHENYLBIGUANIDE
1-phenyl-biguanid
n-phenyl-n’-guanylguanidine
p1426
phenyl-biguanid
phenyldiguanide
2-(N2-Phenylamidino)guanidine | [EINECS(EC#)]
202-998-5 | [Molecular Formula]
C8H11N5 | [MDL Number]
MFCD00179077 | [Molecular Weight]
177.21 | [MOL File]
102-02-3.mol |
| Chemical Properties | Back Directory | [Melting point ]
135-142 °C (lit.) | [Boiling point ]
299.13°C (rough estimate) | [density ]
1.2512 (rough estimate) | [refractive index ]
1.6900 (estimate) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
alcohol: freely soluble | [form ]
powder to crystal | [pka]
10.76, 2.13(at 25℃) | [color ]
White to Orange to Green | [Merck ]
7276 | [InChI]
1S/C8H11N5/c9-7(10)13-8(11)12-6-4-2-1-3-5-6/h1-5H,(H6,9,10,11,12,13) | [InChIKey]
CUQCMXFWIMOWRP-UHFFFAOYSA-N | [SMILES]
NC(=N)\N=C(/N)Nc1ccccc1 | [CAS DataBase Reference]
102-02-3(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H302-H315-H319-H335 | [Precautionary statements ]
P261-P301+P312-P302+P352-P304+P340-P305+P351+P338 | [WGK Germany ]
3
| [RTECS ]
DU2450000
| [HS Code ]
2925.29.6000 | [Storage Class]
11 - Combustible Solids |
| Hazard Information | Back Directory | [Uses]
1-Phenylbiguanide is a 5-hydroxytryptamine receptor agonist. | [Definition]
ChEBI: A member of the class of biguanides that is biguanide in which one of the terminal nitrogen atoms is substituted by a phenyl group. | [General Description]
1-Phenylbiguanide is a 5-hydroxytryptamine receptor agonist and increases extracellular dopamine release in rat nucleus accumbens in vivo. It serves as building block for synthesis of heterocyclic compounds. | [in vivo]
In anaesthetised mice, Phenylbiguanide (PBG), a drug that is known to stimulate cardiopulmonary afferent C-fibres,is injected into the right atrium of the heart and mapped c-Fos expression within specific regions of the central nervous system. Intraatrial injection of PBG produces a reflex cardiorespiratory response including a pronounced bradycardia and a respiratory depression[3]. | [IC 50]
5-HT3 Receptor: 3 μM (EC50) | [Purification Methods]
Crystallise the biguanide from water or toluene. [Beilstein 12 H 370, 12 I 236, 12 III 807.] |
|
| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
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400-0056266 |
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www.energy-chemical.com |
| Company Name: |
Maya High Purity Chemicals
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+86 (573) 82222445 (0)18006601000 452520369 |
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www.chemicalbook.com/ShowSupplierProductsList15221/0_EN.htm |
| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
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