| Identification | Back Directory | [Name]
2-nitro-4-Bromo-5-fluorobenzoic acid | [CAS]
1020717-99-0 | [Synonyms]
4-Bromo-5-fL
uoro-2-nitrobenzoic acid
2-nitro-4-Bromo-5-fluorobenzoic acid
Benzoic acid, 4-bromo-5-fluoro-2-nitro-
4-Bromo-5-fluoro-2-nitrobenzoicacid,98% | [Molecular Formula]
C7H3BrFNO4 | [MDL Number]
MFCD08702773 | [MOL File]
1020717-99-0.mol | [Molecular Weight]
264 |
| Chemical Properties | Back Directory | [Boiling point ]
367.6±42.0 °C(Predicted) | [density ]
1.967±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
crystalline powder | [pka]
1.68±0.25(Predicted) | [color ]
Off-white |
| Hazard Information | Back Directory | [Uses]
2-nitro-4-Bromo-5-fluorobenzoic acid is an important intermediate for the synthesis of a new generation of fluoroquinolone drugs represented by ciprofloxacin.
| [Synthesis]
2,4-Dibromo-5-fluorotoluene was brominated with NBS, hydrolyzed in acid to form aldehyde, and then oxidized by Jones reagent to obtain 2-nitro-4-Bromo-5-fluorobenzoic acid.
| [References]
[1] Patent: CN106146482, 2016, A. Location in patent: Paragraph 0124; 0125; 0126
[2] Patent: WO2017/98440, 2017, A1. Location in patent: Page/Page column 113
[3] Patent: WO2014/128655, 2014, A1. Location in patent: Page/Page column 20
[4] Patent: WO2015/17589, 2015, A1. Location in patent: Page/Page column 42
[5] Patent: US2015/183802, 2015, A1. Location in patent: Paragraph 1175-177 |
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