| Identification | More | [Name]
6-Chloro-2-hexanone | [CAS]
10226-30-9 | [Synonyms]
1-CHLORO-5-HEXANONE
1-CHLOROHEXAN-5-ONE
4-CHLOROBUTYL METHYL KETONE
6-CHLORO-2-HEXANONE
6-CHLOROHEXAN-2-ONE
1-Chlorohexane-5-one
Chlorohexanone
6-CHLORO-2-HEXANONE,98%
6-Chloro-2-hexanol
2-Hexanone, 6-chloro-
Methyl(4-chlorobutyl) ketone | [EINECS(EC#)]
233-546-5 | [Molecular Formula]
C6H11ClO | [MDL Number]
MFCD00191625 | [Molecular Weight]
134.6 | [MOL File]
10226-30-9.mol |
| Chemical Properties | Back Directory | [Appearance]
clear yellow to brown liquid | [Boiling point ]
85.5-86.5 °C/16 mmHg (lit.) | [density ]
1.02 g/mL at 25 °C(lit.)
| [vapor pressure ]
1.29-1.607hPa at 25℃ | [refractive index ]
n20/D 1.4435(lit.)
| [Fp ]
195 °F
| [storage temp. ]
Freezer | [form ]
Liquid | [color ]
Clear yellow to brown | [Specific Gravity]
1.03 | [Water Solubility ]
Insoluble in water, soluble in chloroform (chloroform, carbon), n-heptane, ethanol, butanol, etc. | [InChI]
InChI=1S/C6H11ClO/c1-6(8)4-2-3-5-7/h2-5H2,1H3 | [InChIKey]
CMDIDTNMHQUVPE-UHFFFAOYSA-N | [SMILES]
CC(=O)CCCCCl | [LogP]
1.43-1.492 at 20-25℃ | [CAS DataBase Reference]
10226-30-9(CAS DataBase Reference) |
| Questions And Answer | Back Directory | [Synthesis]
The reaction mixture consisting of 1-alkylcycloalkanol, Pb(OAc)4, and LiCl (total weight ~2g) was mechanically activated in a sealed steel reactor (volume ~80 cm⁻³) containing steel balls with a diameter of 12.3 mm and a total weight of ~150 g, using a vibratory mill with a frequency of 12 Hz and an amplitude of 11 mm. Mechanical activation was carried out for 4 hours. The reaction temperature was increased from 20 °C to 30–35 °C. After the process was completed, the reaction mixture (gray sintered solid) was removed from the reactor. The reaction mixture was washed with diethyl ether (2 x 30 mL) and chloroform (2 x mL) to extract the reaction product. The degree of conversion of the cycloalkanol and the amount of haloalkanone provided were determined by GLC using an internal standard. The degree of conversion of the oxidant was determined by iodometric titration. The organic layer was washed with 3% aqueous HCl and NaHCO3 solution. The organic layer was dried with Na2SO4. Distillation of the organic layer gave the title compound 6-chloro-2-hexanone. |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H227-H315-H319-H335 | [Precautionary statements ]
P210-P280-P370+P378-P403+P235-P501-P210e-P261-P280a-P305+P351+P338-P405-P501a | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [RIDADR ]
NA 1993 / PGIII | [WGK Germany ]
3
| [REACH Registrations]
Active | [HS Code ]
29141990 | [Storage Class]
10 - Combustible liquids |
| Hazard Information | Back Directory | [Chemical Properties]
clear yellow to brown liquid | [Uses]
6-Chloro-2-hexanone in the synthesis of the keto analogs began with 6-chloro-2-hexanone. Substituted 7-(oxoalkyl)theophyllines were synthesized by alkylation of the respective theophyllines with 6-chloro-2-hexanone. | [Synthesis Reference(s)]
The Journal of Organic Chemistry, 21, p. 140, 1956 DOI: 10.1021/jo01107a033 | [Flammability and Explosibility]
Nonflammable |
|
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J & K SCIENTIFIC LTD.
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China Langchem Inc.
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