| Identification | Back Directory | [Name]
3BETA-HYDROXY-5-CHOLESTENE 3-HEMISUCCINATE TRIS SALT | [CAS]
102601-49-0 | [Synonyms]
CHEMS
CHOLESTERYL HEMISUCCINATE TRIS
CHOLESTERYL HEMISUCCINATE TRIS SALT
3β-hydroxy-5-cholestene 3-hemisuccinate
CHOLESTERYL HYDROGEN SUCCINATE TRIS SALT
CHOLESTERYL HEMISUCCINATE F & D VERSION&
5-CHOLESTEN-3BETA-OL 3-HEMISUCCINATE TRIS SALT
3BETA-HYDROXY-5-CHOLESTENE 3-HEMISUCCINATE TRIS SALT
Cholesteryl hemisuccinate tris salt anionic detergent
4-[[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-4-oxobutanoic acid | [Molecular Formula]
C35H61NO7 | [MDL Number]
MFCD00058298 | [MOL File]
102601-49-0.mol | [Molecular Weight]
607.87 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [form ]
powder | [color ]
White to off-white | [biological source]
synthetic (organic) | [InChIKey]
SLDYONDUXRBLLR-XTCKSVDZSA-N | [SMILES]
NC(CO)(CO)CO.CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)OC(=O)CCC(O)=O |
| Hazard Information | Back Directory | [Uses]
Cholesteryl hemisuccinate tris salt has been used:
- to prepare solubilization buffer for glucan synthase assay
- to prepare immunoprecipitation buffer for immobilization of opioid receptors on paramagnetic beads.
- as a membrane stabilizer for liposomes and protein synaptogyrin-1
- as a component of a folate-modified self-microemulsifying drug delivery system.
- with N-dodecyl β-D-maltoside (DDM) to solubilize erythrocyte ghosts and chemokine receptor CCR1
- for protein solubilization
| [Biochem/physiol Actions]
Cholesteryl hemisuccinate is an ionizable anionic detergent that stabilizes large unilamellar vesicles. These liposome vesicles act as delivery agents for anticancer drugs, oligonucleotides and antibiotics. Cholesteryl succinate also reportedly exhibits antiproliferative activity and may be clinically useful as antitumor agent. |
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Sigma-Aldrich
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DC Chemicals
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Energy Chemical
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Merck KGaA
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