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77-86-1

77-86-1 Structure

77-86-1 Structure
IdentificationMore
[Name]

Trometamol
[CAS]

77-86-1
[Synonyms]

2-AMINO-2-HYDROXYMETHYL
2-AMINO-2-(HYDROXYMETHYL)-1,3-PROPANEDIOL
2-AMINO-2-(HYDROXYMETHYL)PROPANE-1,3-DIOL
2-AMINO-(HYDROXYMETHYL)-1,3-PROPANEDIOL
2-HYDROXYMETHYL-2-AMINO-1,3-PROPANEDIOL
4G 1MTRIS, PH 8.0
8VTE 1L
AMINOMETHYLIDINE TRIMETHANOL
ATX TRIS BUFFER
BUFFER TRIS
MOLE-READY-TRIS BASE
SIGMA 7-9(R)
SPECTRIS(R)
SPECTRIS(TM)
THAM
TIMTEC-BB SBB006714
TRI(HYDROXYMETHYL)AMINOMETHANE
TRIMETHYLOL AMINOMETHANE
TRIS
TRISAMINE
[EINECS(EC#)]

201-064-4
[Molecular Formula]

C4H11NO3
[MDL Number]

MFCD00004679
[Molecular Weight]

121.14
[MOL File]

77-86-1.mol
Questions And AnswerBack Directory
[Chemical Properties]

White crystal or powder. Melting point 171-172℃, boiling point 219-220℃/1.3kPa, soluble in ethanol and water, slightly soluble in ethyl acetate, benzene, insoluble in ether, carbon tetrachloride,copper,aluminum corrosion effects,irritant.
[Uses of Biology]

Tris base, also known as THAM, is widely used as a biological buffer or as a component of buffer formulations such as TAE and TBE buffers. Tris has a pKa of 8.06 and is very useful in the biology and biochemistry lab because it has buffering capabilities in the range of the typical physiological pH of most living organisms (pH 7.0-9.0). Tris has been reported to interfere with the activity of a number of enzymes, it should therefore be used carefully when studying proteins.
[Uses]

1, Tris buffer, only nucleic acids and proteins are widely used as solvents.
2, Tris is used for protein crystal growth under different pH conditions.
3, Tris buffer having a low ionic strength can be used nematode (C. elegans) is formed lamin (lamin) intermediate fibers.
4, Tris is a major component of protein electrophoresis buffer.
5, Tris for the preparation of a surfactant, a vulcanization accelerator, and some drug intermediates.
6, Tris titrated also used as standard.
Chemical PropertiesBack Directory
[Appearance]

White crystalline powder
[Appearance]

White, crystalline solid. PH (0.1M aqueous solution) 10.6, corrosive to copper, brass, aluminum. Solubility in water 80 g/100 cc (20C). Combustible.
[mp ]

167-172 °C(lit.)
[bp ]

219-220 °C10 mm Hg(lit.)
[density ]

1,353 g/cm3
[Fp ]

219-220°C/10mm
[storage temp. ]

2-8°C
[solubility ]

H2O: 4 M at 20 °C, clear, colorless
[form ]

crystalline
[color ]

white
[Stability:]

Stable. Incompatible with bases, strong oxidizing agents. Protect from moisture.
[Water Solubility ]

550 g/L (25 ºC)
[Sensitive ]

Hygroscopic
[Detection Methods]

T,MP
[Detection Methods]

T,NMR
[Detection Methods]

T,NMR,MS
[Merck ]

14,9772
[BRN ]

741883
[Uses]

tromethamine can help mask odor in a formulation. It is also used as a buffer, keeping product pH stable.
[CAS DataBase Reference]

77-86-1(CAS DataBase Reference)
[NIST Chemistry Reference]

1,3-Propanediol, 2-amino-2-(hydroxymethyl)-(77-86-1)
[EPA Substance Registry System]

77-86-1(EPA Substance)
Safety DataBack Directory
[Hazard Codes ]

Xi
[Risk Statements ]

R36/37/38:Irritating to eyes, respiratory system and skin .
[Safety Statements ]

S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection .
[WGK Germany ]

2
[RTECS ]

TY2900000
[F ]

3
[HS Code ]

29221980
[Hazardous Substances Data]

77-86-1(Hazardous Substances Data)
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Methanol-->Potassium carbonate-->Palladium-->Paraformaldehyde-->Nitromethane-->Tris(hydroxymethyl)nitromethane
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

2-Amino-2-(hydroxymethyl)-1,3-propanediol(77-86-1).msds
Spectrum DetailBack Directory
[Spectrum Detail]

Tris Base(77-86-1)MS
Tris Base(77-86-1)IR1
Tris Base(77-86-1)13CNMR
Tris Base(77-86-1)IR2
Tris Base(77-86-1)1HNMR
Well-known Reagent Company Product InformationBack Directory
[Acros Organics]

Tris(hydroxymethyl)aminomethane, for biochemistry, 99+%(77-86-1)
[Alfa Aesar]

Tris(hydroxymethyl)aminomethane, ACS, 99.8-100.1% (Assay, dried basis)(77-86-1)
[Sigma Aldrich]

77-86-1(sigmaaldrich)
[TCI AMERICA]

Tris(hydroxymethyl)aminomethane,>99.0%(T)(77-86-1)
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