| Identification | Back Directory | [Name]
KINETENSIN | [CAS]
103131-69-7 | [Synonyms]
NRP
IARRHPYFL
KINETENSIN
Human kinetensin
KINETENSIN (HUMAN)
Kinetensin, ≥97% (HPLC)
253: PN: WO0069900 SEQID
NEUROTENSIN-RELATED PEPTIDE
ILE-ALA-ARG-ARG-HIS-PRO-TYR-PHE-LEU
WO0239997 SEQID: 1 unclaimed sequence
H-ILE-ALA-ARG-ARG-HIS-PRO-TYR-PHE-LEU-OH
L-Leucine, L-isoleucyl-L-alanyl-L-arginyl-L-arginyl-L-histidyl-L-prolyl-L-tyrosyl-L-phenylalanyl- | [Molecular Formula]
C56H85N17O11 | [MDL Number]
MFCD00167613 | [MOL File]
103131-69-7.mol | [Molecular Weight]
1172.38 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C
| [solubility ]
TFA 0.1%: 1 mg/mL, clear, colorless
| [form ]
Powder | [color ]
White to off-white | [Water Solubility ]
Soluble to 2 mg/ml in water | [Sequence]
Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe-Leu |
| Hazard Information | Back Directory | [Uses]
Kinetensin is a neurotensin-like peptide isolated from pepsin-treated human plasma. | [Definition]
ChEBI: Kinetensin is an oligopeptide comprising of nine amino acids with sequence L-Ile-L-Ala-L-Arg-L-Arg-L-His-L-Pro-L-Tyr-L-Phe-L-Leu. It was originally isolated from pepsin-treated human plasma and shares some sequence homology with the C-terminal end of neurotensin. It is a potent histamine releaser and may serve as an inflammatory mediator. It has a role as a human metabolite and a histamine releasing agent. It is a conjugate base of a kinetensin(2+). | [in vivo]
Kinetensin also induces a dose-dependent increase in vascular permeability when injected intradermally into rats[2]. | [IC 50]
Human Endogenous Metabolite | [References]
[1] Mogard MH, et al. The amino acid sequence of kinetensin, a novel peptide isolated from pepsin-treated human plasma: homology with human serum albumin, neurotensin and angiotensin. Biochem Biophys Res Commun. 1986 May 14;136(3):983-8. DOI:10.1016/0006-291x(86)90429-8
[2] Sydbom A, et al. Stimulation of histamine release by the peptide kinetensin. Agents Actions. 1989 Apr;27(1-2):68-71. DOI:10.1007/BF02222201 |
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