| Identification | Back Directory | [Name]
5-FLUORO-2'-DEOXYURIDINE 5'-MONOPHOSPHATE SODIUM SALT | [CAS]
103226-10-4 | [Synonyms]
5-FdUMP·Na2
5-Fluoro-2′-deoxyuridine 5′-monophosphate
2'-Deoxy-5-fluoro-5'-uridylic acid disodium salt
5-FLUORO-2'-DEOXYURIDINE-5'-*MONOPHOSPHA TE SODIUM
5'-Uridylic acid, 2'-deoxy-5-fluoro-, disodiuM salt
5-Fluoro-2’deoxyuridine 5’Monophosphate Disodium Salt
5-FLUORO-2'-DEOXYURIDINE 5'-MONOPHOSPHATE SODIUM SALT
2'-Deoxy-5-fluorouridine 5'-monophosphate sodium salt
5-Fluoro-2'-deoxyuridine-5'-O-monophosphate, sodium salt
5'-Uridylic acid,2'-deoxy-5-fluoro-, disodium salt (9CI)
Sodium ((2R,3S,5R)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl phosphate | [Molecular Formula]
C9H11FN2NaO8P | [MDL Number]
MFCD00057409 | [MOL File]
103226-10-4.mol | [Molecular Weight]
348.15 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
water: 50 mg/mL, clear, colorless to faint yellow or tan | [form ]
solid | [InChI]
1S/C9H12FN2O8P.Na.H/c10-4-2-12(9(15)11-8(4)14)7-1-5(13)6(20-7)3-19-21(16,17)18;;/h2,5-7,13H,1,3H2,(H,11,14,15)(H2,16,17,18);; | [InChIKey]
DGEOOGBABXVZPJ-UHFFFAOYSA-N | [SMILES]
[Na].OC1CC(OC1COP(O)(O)=O)N2C=C(F)C(=O)NC2=O |
| Hazard Information | Back Directory | [Uses]
5-Fluoro-2’deoxyuridine 5’Monophosphate is used in the preparation of diaminomitosene nucleotide derivatives with anti-neoplastic activity. | [Uses]
5-Fluoro-2′-deoxyuridine 5′-monophosphate (FdUMP) is used extensively in studies on the activity and function of thymidylate synthase (TS). | [Uses]
5-Fluoro-2′-deoxyuridine 5′-monophosphate sodium salt has been used as an anti-mitotic agent and is used extensively in studies on the activity and function of thymidylate synthase (TS). | [Biochem/physiol Actions]
5-Fluoro-2′-deoxyuridine 5′-monophosphate sodium salt (FdUMP) is an DNA synthesis inhibitor. FdUMP along with RNA synthesis inhibitor 3′-C-ethinylcytidine induces cell death in cervical cancer cells at nanomolar concentrations. |
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Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
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