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Diallyl isosorbide ether (I) was synthesized from 3-bromo-1-propene and isosorbitol by Williamson reaction (Scheme 1). The procedure was as follows: isosorbide (3 g, 20.4 mmol) was dissolved in 50% NaOH aqueous solution (6 g, 107.2 mmol). Tetrabutylammonium bromide (TBAB, 300 mg, 0.94 mmol) at 4.5% relative to isosorbide was added to the reaction system as a phase-transfer catalyst, and allyl bromide (10 mL, 115.7 mmol) was used as an alkylation reagent. The reaction mixture was heated and stirred at 65 °C for 4 hours. After completion of the reaction, the mixture was extracted using dichloromethane. The organic phase was washed sequentially with 1 M HCl and water to remove salt impurities. The final product was purified by reduced pressure distillation (108 °C/1 torr) to obtain the pure product in 88% yield.