| Identification | Back Directory | [Name]
3-aminopropylphosphinic acid | [CAS]
103680-47-3 | [Synonyms]
3-APPA
CGP-27492
CGA147823
3-APPA (CGP 27492)
3-aminopropylphosphinic acid
Phosphinic acid, P-(3-aminopropyl)- | [Molecular Formula]
C3H10NO2P | [MDL Number]
MFCD05662182 | [MOL File]
103680-47-3.mol | [Molecular Weight]
123.09 |
| Hazard Information | Back Directory | [Uses]
3-Aminopropylphosphinic acid (3-APPA) is a phosphonic analog of GABA. 3-Aminopropylphosphinic acid is a potent, selective GABAB receptor agonist[1]. | [in vivo]
3-Aminopropylphosphinic acid (5 mg/kg; i.v.) blocks the inhibitory effects of GABA against vagal broncho-spasm in guinea pigs[3]. | Animal Model: | guinea pigs[3] | | Dosage: | 5 mg/kg | | Administration: | IV | | Result: | Blocked the inhibitory effects of GABA against vagal broncho-spasm. |
| [References]
[1] Luzzi S, Franchi-Micheli S, Ciuffi M, Pajani A, Zilletti L. GABA-related activities of amino phosphonic acids on guinea-pig ileum longitudinal muscle. J Auton Pharmacol. 1986 Sep;6(3):163-9. DOI:10.1111/j.1474-8673.1986.tb00641.x
[2] Hills JM, Dingsdale RA, Parsons ME, Dolle RE, Howson W. 3-Aminopropylphosphinic acid--a potent, selective GABAB receptor agonist in the guinea-pig ileum and rat anococcygeus muscle. Br J Pharmacol. 1989 Aug;97(4):1292-6. DOI:10.1111/j.1476-5381.1989.tb12591.x
[3] Chapman RW, Danko G, Rizzo C, Egan RW, Mauser PJ, Kreutner W. Prejunctional GABA-B inhibition of cholinergic, neurally-mediated airway contractions in guinea-pigs. Pulm Pharmacol. 1991;4(4):218-24. DOI:10.1016/0952-0600(91)90014-t
[4] Cho Youn-Ki, et al. 3-Aminopropyl dihydrogen phosphate (3-APPA; 3-aminopropane phosphoric acid); a novel anti-aging substance. Journal of Investigative Dermatology, vol. 4, no. 106, 2015, p. 895. |
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