| Identification | Back Directory | [Name]
5-Maleimidovalericacid-NHS | [CAS]
103750-03-4 | [Synonyms]
Mal-C2-NHS ester
5-Maleimidovalericacid-NHS
5-Maleimido-pentanoic NHS ester
5-Maleimidopentanoic acid-NHS ester
2,5-dioxopyrrolidin-1-yl 5-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)
2,5-dioxopyrrolidin-1-yl 5-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)pentanoate
1H-Pyrrole-1-pentanoicacid, 2,5-dihydro-2,5-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester | [Molecular Formula]
C13H14N2O6 | [MDL Number]
MFCD01318603 | [MOL File]
103750-03-4.mol | [Molecular Weight]
294.26 |
| Chemical Properties | Back Directory | [Boiling point ]
472.3±47.0 °C(Predicted) | [density ]
1.44±0.1 g/cm3(Predicted) | [solubility ]
Soluble in DMSO, DCM, DMF | [form ]
Solid | [pka]
-2.23±0.20(Predicted) | [color ]
White to light yellow | [InChI]
InChI=1S/C13H14N2O6/c16-9-4-5-10(17)14(9)8-2-1-3-13(20)21-15-11(18)6-7-12(15)19/h4-5H,1-3,6-8H2 | [InChIKey]
ULZJAHZPCLFGHQ-UHFFFAOYSA-N | [SMILES]
N1(CCCCC(ON2C(=O)CCC2=O)=O)C(=O)C=CC1=O |
| Hazard Information | Back Directory | [Description]
5-Maleimido-pentanoic NHS ester contains a maleimide group and an NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. | [Chemical Properties]
White powder | [Uses]
Mal-C2-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. | [IC 50]
Non-cleavable Linker | [References]
[1] Andrew Wood, et al. Processes for the synthesis and purification of heterobifunctional cross-linkers. WO2011023680A2. |
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| Company Name: |
Energy Chemical
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021-021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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