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64987-85-5

64987-85-5 Structure

64987-85-5 Structure
IdentificationMore
[Name]

N-Succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate
[CAS]

64987-85-5
[Synonyms]

4-(N-MALEIMIDOMETHYL)CYCLOHEXANE-1-CARBOXYLIC ACID N-HYDROXYSUCCINIMIDE ESTER
4-(N-MALEIMIDOMETHYL)CYCLOHEXANECARBOXYLIC ACID N-HYDROXYSUCCINIMIDE ESTER
N-SUCCINIMIDYL 4-(MALEIMIDOMETHYL)CYCLOHEXANE-1-CARBOXYLATE
N-SUCCINIMIDYL 4-(MALEIMIDOMETHYL)CYCLOHEXANECARBOXYLATE
SMCC
SUCCINIMIDYL 4-[N-MALEIMIDO-METHYL]CYCLOHEXANE-1-CARBOXYLATE
SUCCINIMIDYL TRANS-4-(MALEIMIDYLMETHYL)CYCLOHEXANE-1-CARBOXYLATE
SUCCINIMIDYL-TRANS-4-(N-MALEIMIDOMETHYL)CYCLOHEXANE-1-CARBOXYLATE
SUCCINIMIDYL-TRANS-4-(N-MALEIMIDYLMETHYL)CYCLOHEXANE-1-CARBOXYLATE
TRANS-4-(N-MALEIMIDYLMETHYL)-CYCLO-HEXANE-1-CARBOXYLATE-N-HYDROXYSUCCINIMIDE ESTER
n-(4-carboxycyclohexylmethyl)maleimiden-hydroxysuccinimideester
N-succinimidyl 4-(maleimidome.)cyclo-hexanecarboxylate
4-(N-MALEIMIDOMETHYL)-CYCLOHEXANE-1-CARBOXYLIC ACID N-HYDROXYSUCCINIMIDE ESTER CRYSTALLINE
N-Succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate
4-(maleimidomethyl)-1-cyclohexanecarboxylic acid N-hydroxy
N-Succinimidyl 4-(maleimidomethyl)cyclohexanecarboxylate, SMCC
[EINECS(EC#)]

1592732-453-0
[Molecular Formula]

C16H18N2O6
[MDL Number]

MFCD00009634
[Molecular Weight]

334.32
[MOL File]

64987-85-5.mol
Chemical PropertiesBack Directory
[Appearance]

White Crystalline Solid
[Melting point ]

180-182 °C (lit.)
[mp ]

180-182 °C(lit.)
[Boiling point ]

501.7±42.0 °C(Predicted)
[density ]

1.42±0.1 g/cm3(Predicted)
[storage temp. ]

2-8°C
[solubility ]

chloroform: 50 mg/mL
[form ]

powder
[pka]

-2.24±0.20(Predicted)
[Usage]

A sulfhydryl and amino reactive heterobifunctional protein crosslinking reagent. It conjugates anti-digoxin F(ab?2 fragments to ?galactosidase. Conjugates hIgG to alkaline phosphatase. Spacer Arm: 11.6 Angstrom
[Sensitive ]

Moisture & Light Sensitive
[BRN ]

1555271
[CAS DataBase Reference]

64987-85-5(CAS DataBase Reference)
Safety DataBack Directory
[Hazard Codes ]

Xi
[Risk Statements ]

R36/37/38:Irritating to eyes, respiratory system and skin .
[Safety Statements ]

S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
[WGK Germany ]

3
[F ]

10-21
[HS Code ]

29280000
Hazard InformationBack Directory
[Chemical Properties]

White Crystalline Solid
[Uses]

A sulfhydryl and amino reactive heterobifunctional protein crosslinking reagent. It conjugates anti-digoxin F(ab’)2 fragments to ?-galactosidase. Conjugates hIgG to alkaline phosphatase. Spacer Arm: 11.6 Angstroms
[Definition]

ChEBI: An N-hydroxysuccinimide ester derived from 4-(N-maleimidomethyl)cyclohexane-1-carboxylic acid.
[General Description]

4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester (SMCC) is a heterobifunctional cross-linking reagent incorporating an extended spacer with amine and sulfhydryl reactivity. It is typically coupled initially to molecules containing primary amine by amide bond buffered at pH 7.5 (6.5-8.5). The second coupling is specific for molecules containing free sulfhydryl by thioether linkage buffered at pH 6.8 (6.5-7.0). SMCC contains nine atom linker. An extended aliphatic spacer stabilizes the maleimide prior to coupling compared to aromatic spacers.
Well-known Reagent Company Product InformationBack Directory
[Sigma Aldrich]

64987-85-5(sigmaaldrich)
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