| Identification | Back Directory | [Name]
CAY10622 | [CAS]
1038549-25-5 | [Synonyms]
CAY10622
ROCK-IN-10
CAY10622 Exclusive
3-[[(4-carbamoylphenyl)carbamoylamino]methyl]-N-(1,2,3,4-tetrahydroisoquinolin-7-yl)benzamide
BenzaMide, 3-[[[[[4-(aMinocarbonyl)phenyl]aMino]carbonyl]aMino]Methyl]-N-(1,2,3,4-tetrahydro-7-isoquinolinyl)- | [Molecular Formula]
C25H25N5O3 | [MOL File]
1038549-25-5.mol | [Molecular Weight]
443.5 |
| Hazard Information | Back Directory | [Description]
Two Rho-associated kinases (ROCK), ROCK1 and ROCK2, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. CAY10622 is a potent, ureidobenzamide inhibitor of ROCK1 and ROCK2 with IC50 values of 6 and 4 nM, respectively. It is inactive (showing greater then 100-fold selectivity) against an additional 44 kinases. | [Uses]
Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. CAY10622 is a potent, ureidobenzamide inhibitor of ROCK-I and ROCK-II kinases with IC50 values of 6 and 4 nM, respectively. It is inactive (showing greater then 100-fold selectivity) against an additional 44 kinases.[Cayman Chemical] | [References]
[1] TINA MORWICK. Hit to Lead Account of the Discovery of Bisbenzamide and Related Ureidobenzamide Inhibitors of Rho Kinase[J]. Journal of Medicinal Chemistry, 2009, 53 2: 759-777. DOI: 10.1021/jm9014263 |
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