| Identification | Back Directory | [Name]
macrocalin A | [CAS]
10391-08-9 | [Synonyms]
Isodocarpin
13-Deoxyenmein
(-)-Isodocarpin
(-)-Isodocarpin
(10bS)-1,2,3,3aβ,8,9,10,10aα,13,13aβ-Decahydro-13β-hydroxy-1,1-dimethyl-7-methylene-5H-5aβ,8β-methanocyclohepta[c]furo[3,4-e][1]benzopyran-5,6(7H)-dione | [Molecular Formula]
C12H26 | [MOL File]
10391-08-9.mol | [Molecular Weight]
170.335 |
| Hazard Information | Back Directory | [Uses]
(-)-Isodocarpin (Isodocarpin), a diterpenoid, is a potent melanogenesis inhibitor with an IC50 of 0.19 μM in B16 4A5 cells. (-)-Isodocarpin inhibits the expression of tyrosinase, tyrosine-related protein (TRP)-1, and TRP-2 mRNA[1]. | [References]
[1] Yoshiaki Manse, et al. Melanogenesis Inhibitory Activity of Diterpenoid and Triterpenoid Constituents from the Aerial Part of Isodon trichocarpus. Natural Product Communications. August 1, 2017. |
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