| Identification | Back Directory | [Name]
(4-methoxy-1H-indol-2-yl)-(1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl)methanone | [CAS]
1040706-91-9 | [Synonyms]
NPD10084
(4-methoxy-1H-indol-2-yl)-(1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl)methanone
Methanone, (4-methoxy-1H-indol-2-yl)(1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)- | [Molecular Formula]
C21H19N3O2 | [MDL Number]
MFCD12029753 | [MOL File]
1040706-91-9.mol | [Molecular Weight]
345.39 |
| Chemical Properties | Back Directory | [Boiling point ]
640.1±55.0 °C(Predicted) | [density ]
1.364±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
15.92±0.30(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
NPD10084 is a pyruvate kinase PKM2 inhibitor that inhibits non-glycolytic signaling in cancer cells. NPD10084 disrupts the interaction between PKM2 and β-catenin or STAT3 and inhibits downstream signaling. NPD10084 has antiproliferative activity against colorectal cancer cells in vitro and in vivo[1]. | [References]
[1] Nagasawa I, et al. Identification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSA. Cell Chem Biol. 2020 Feb 20;27(2):186-196.e4. DOI:10.1016/j.chembiol.2019.11.010 |
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PHARMEKS Ltd.
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+7 (495) 702-9648 |
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www.pharmeks.com |
| Company Name: |
OTAVA chemicals
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416 305 9979 (Canada) |
| Website: |
www.otavachemicals.com |
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