| Identification | Back Directory | [Name]
jnj39758979 | [CAS]
1046447-90-8 | [Synonyms]
jnj39758979
JNJ 39758979
(JNJ-39758979
(R)-4-(3-aminopyrrolidin-1-yl)-6-isopropylpyrimidin-2-amine
4-[(3R)-3-AMINOPYRROLIDIN-1-YL]-6-PROPAN-2-YLPYRIMIDIN-2-AMINE
2-Pyrimidinamine, 4-[(3R)-3-amino-1-pyrrolidinyl]-6-(1-methylethyl)- | [Molecular Formula]
C11H19N5 | [MDL Number]
MFCD28502028 | [MOL File]
1046447-90-8.mol | [Molecular Weight]
221.3 |
| Chemical Properties | Back Directory | [storage temp. ]
4°C, protect from light | [solubility ]
Chloroform (Slightly), DMSO (Slightly, Sonicated) | [form ]
Solid | [color ]
Pale Beige to Light Beige |
| Hazard Information | Back Directory | [Uses]
JNJ 39758979, is a selective, high-affinity histamine H4 receptor antagonist with a Ki of 12.5 nM. | [in vivo]
JNJ-39758979 (10 mg/kg; p.o.) treatment shows that the Cmax, t1/2 and F values are 0.3 μM, 7.5 hours, and 36%, respectively[1].
JNJ-39758979 (2 mg/kg; i.v.) treatment shows that the Vss, AUC, CL and t1/2 were 19.9 L/kg, 1.4 μM*h, 2.2 L/h, and 2.1 hours, respectively [1]. | Animal Model: | Sprague-Dawley rats[1] | | Dosage: | 10 mg/kg | | Administration: | Oral administration (Pharmacokinetic Analysis) | | Result: | The Cmax, t1/2 and F values were 0.3 μM, 7.5 hours, and 36%, respectively.
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| [IC 50]
Human H4 Receptor: 12.5 nM (Ki); Mouse H4 Receptor: 5.3 nM (Ki); Monkey H4 receptor: 25 nM (Ki); Rat H4 receptor: 188 nM (Ki); Guinea pig H4 receptor: 306 nM (Ki) |
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