| Identification | Back Directory | [Name]
4-[3-(Trifluoromethyl)-2-pyridinyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxamide | [CAS]
821768-06-3 | [Synonyms]
JNJ 17203212
JNJ-17203212
(JNJ17203212
N1-(3-Trifluoromethylpyrid-2-yl)-N4-(4-trifluoromethylpyrid-2-yl)carbamoylpiperazine
4-[3-(Trifluoromethyl)-2-pyridinyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxamide
1-PiperazinecarboxaMide, 4-[3-(trifluoroMethyl)-2-pyridinyl]-N-[5-(trifluoroMethyl)-2-pyridinyl]- | [Molecular Formula]
C17H15F6N5O | [MDL Number]
MFCD12828764 | [MOL File]
821768-06-3.mol | [Molecular Weight]
419.32 |
| Chemical Properties | Back Directory | [Boiling point ]
551.315±50.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.472±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
DMSO: >20mg/mL | [form ]
Powder | [pka]
9.323±0.46(predicted) | [color ]
white to off-white |
| Hazard Information | Back Directory | [Uses]
JNJ 17203212 is a high affinity TRPV1 receptor antagonist. | [in vivo]
JNJ-17203212 (0.3 mg/kg; i.v.) dose-dependently reduces inflammatory soup (IS)-induced the immediate early gene c-fos expression[2].
JNJ-17203212 completely blocks capsaicin-induced CGRP (the neurotransmitter calcitonin gene-related peptide) release in a dose-dependent manner[2].
| Animal Model: | Male Sprague-Dawley rats (260-300 g)[2] | | Dosage: | 0.3 mg/kg | | Administration: | Intravenous injection | | Result: | Had a dose-dependent effect on the elevated c-fos expression that occurred after intracisternal injection of IS. |
| [IC 50]
TRPV1 | [storage]
Store at +4°C |
|
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BOC Sciences
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Lynnchem
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https://www.novachemistry.com/ |
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