| Chemical Properties | Back Directory | [Boiling point ]
593.721±60.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.439±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [solubility ]
Dichloromethane: Slightly soluble
DMSO: Slightly soluble
Methanol: Slightly soluble | [pka]
4.594±0.10(predicted) |
| Hazard Information | Back Directory | [Uses]
S 8849-1 (free base) (Tianeptine metabolite MC5) is a Tianeptine (HY-90003) metabolite that is found in plasma. The mean elimination half-lives of S 8849-1 (free base) is 7.53 h in rats. S 8849-1 (free base) is promising for research of antidepressants[1][2]. | [References]
[1] Gaulier JM, et al. High-performance liquid chromatographic determination of tianeptine in plasma applied to pharmacokinetic studies. J Chromatogr B Biomed Sci Appl. 2000 Oct 10;748(2):407-14. DOI:10.1016/s0378-4347(00)00368-6
[2] Szafarz M, et al. Pharmacokinetic study of tianeptine and its active metabolite MC5 in rats following different routes of administration using a novel liquid chromatography tandem mass spectrometry analytical method. Naunyn Schmiedebergs Arch Pharmacol. 2018 Feb;391(2):185-196. DOI:10.1007/s00210-017-1448-2 |
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