105228-46-4

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105228-46-4 Structure

Identification	Back Directory
[Name] Benzyl (2S,3R)-(+)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate
[CAS] 105228-46-4
[Synonyms] 6-oxo-2 Benzyl (2S 3-diphenyl- 4-Morpholinecarboxylicacid (2S,3R)-N-CBZ-6-OXO-2,3- DIPHENYLMORPHOLINE (2S,3R)-(+)-N-Z-6-oxo-2,3-diphenylMorpholine (2S,3R)-benzyl 6-oxo-2,3- diphenylmorpholine-4-carboxylate (5S,6R)-(+)-4-Benzyloxycarbonyl-5,6-diphenyl-2-Morpholinone (2S,3R)-(+)-N-Benzyloxycarbonyl-6-oxo-2,3-diphenylMorpholine BENZYL (2S,3R)-(+)-6-OXO-2,3-DIPHENYL-4-MORPHOLINECARBOXYLATE Benzyl (2S,3R)-6-Oxo-2,3-diphenyl-4-morpholinecarbox ylate,99%e.e. (2S,3R)-6-oxo-2,3-diphenyl-4-morpholinecarboxylic acid (phenylmethyl) ester 4-Morpholinecarboxylic acid, 6-oxo-2,3-diphenyl-, phenylmethyl ester, (2S,3R)- (5R,6S)-4-(benzyloxycarbonyl)-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one (2S,3R)-(+)-N-Z-6-oxo-2,3-diphenylMorpholine
[Molecular Formula] C24H21NO4
[MDL Number] MFCD00074956
[MOL File] 105228-46-4.mol
[Molecular Weight] 387.43

Chemical Properties	Back Directory
[Melting point ] 205-207 °C(lit.)
[alpha ] 66 º (c=5.5 in methylene chloride)
[Boiling point ] 583.5±50.0 °C(Predicted)
[density ] 1.242±0.06 g/cm3(Predicted)
[storage temp. ] 2-8°C
[pka] -3.33±0.60(Predicted)
[Appearance] White to off-white Solid
[Optical Rotation] [α]25/D +66°, c = 5.5 in methylene chloride
[InChI] InChI=1S/C24H21NO4/c26-21-16-25(24(27)28-17-18-10-4-1-5-11-18)22(19-12-6-2-7-13-19)23(29-21)20-14-8-3-9-15-20/h1-15,22-23H,16-17H2/t22-,23+/m1/s1
[InChIKey] HECRUWTZAMPQOS-PKTZIBPZSA-N
[SMILES] N1(C(OCC2=CC=CC=C2)=O)CC(=O)O[C@@H](C2=CC=CC=C2)[C@H]1C1=CC=CC=C1

Safety Data	Back Directory
[Hazard Codes ] Xi
[Risk Statements ] 36/37/38
[Safety Statements ] 26-37/39
[WGK Germany ] 3
[HS Code ] 29349990
[Storage Class] 11 - Combustible Solids
[Hazard Classifications] Eye Irrit. 2 Skin Irrit. 2 STOT SE 3

[Uses]

(2S,3R)-(+)-N-Z-6-oxo-2,3-diphenylmorpholine can be used as a starting material for the synthesis of:

α-Amino-β-silyloxy-ester, a key intermediate for the preparation of antimalarial drug quinine and its analogs.
R, R-Formylglycine dimethylacetal, a key intermediate for the preparation of tuberculostatic compound capreomycin IB.
2R,5R,6S-2-(Methoxycarbonylmethyl)-5,6-diphenylmorpholine hydrochloride, a key intermediate for the preparation of an antibiotic (+)-negamycin.

Spectrum Detail	Back Directory
[Spectrum Detail] Benzyl (2S,3R)-(+)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate(105228-46-4)¹HNMR Benzyl (2S,3R)-(+)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate(105228-46-4)Raman Benzyl (2S,3R)-(+)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate(105228-46-4)IR

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